Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 5051146..5051748 Replicon chromosome
Accession NZ_CP086625
Organism Escherichia coli strain RIVM_C037166

Toxin (Protein)


Gene name higB Uniprot ID A0A4Y9BEM6
Locus tag LN360_RS24595 Protein ID WP_059332311.1
Coordinates 5051437..5051748 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LN360_RS24590 Protein ID WP_000356395.1
Coordinates 5051146..5051436 (-) Length 97 a.a.

Genomic Context


LN360_RS24555LN360_RS24560LN360_RS24565LN360_RS24600LN360_RS24570LN360_RS24575LN360_RS24580LN360_RS24585LN360_RS24590LN360_RS24595LN360_RS24605LN360_RS24610LN360_RS24615LN360_RS24620
Location: 5046770..5047672 (903 bp)
Type: Others
Protein ID: WP_000331377.1
Location: 5047669..5048304 (636 bp)
Type: Others
Protein ID: WP_000829013.1
Location: 5048301..5049230 (930 bp)
Type: Others
Protein ID: WP_000027720.1
Location: 5051977..5052885 (909 bp)
Type: Others
Protein ID: WP_001550353.1
Location: 5049412..5049654 (243 bp)
Type: Others
Protein ID: WP_001309881.1
Location: 5049873..5050091 (219 bp)
Type: Others
Protein ID: WP_001295676.1
Location: 5050510..5050788 (279 bp)
Type: Others
Protein ID: WP_001315112.1
Location: 5050840..5051061 (222 bp)
Type: Others
Protein ID: WP_001550354.1
Location: 5051146..5051436 (291 bp)
Type: Antitoxin
Protein ID: WP_000356395.1
Location: 5051437..5051748 (312 bp)
Type: Toxin
Protein ID: WP_059332311.1
Location: 5053053..5053967 (915 bp)
Type: Others
Protein ID: WP_109553727.1
Location: 5053980..5054867 (888 bp)
Type: Others
Protein ID: Protein_4814
Location: 5055283..5056224 (942 bp)
Type: Others
Protein ID: WP_001297068.1
Location: 5056269..5056706 (438 bp)
Type: Others
Protein ID: WP_000560983.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LN360_RS24555 (5046770)5046770..5047672+903WP_000331377.1formate dehydrogenase O subunit beta-
LN360_RS24560 (5047669)5047669..5048304+636WP_000829013.1formate dehydrogenase cytochrome b556 subunit-
LN360_RS24565 (5048301)5048301..5049230+930WP_000027720.1formate dehydrogenase accessory protein FdhE-
LN360_RS24570 (5049412)5049412..5049654-243WP_001309881.1CopG family transcriptional regulator-
LN360_RS24575 (5049873)5049873..5050091-219WP_001295676.1CopG family transcriptional regulator-
LN360_RS24580 (5050510)5050510..5050788-279WP_001315112.1hypothetical protein-
LN360_RS24585 (5050840)5050840..5051061-222WP_001550354.1hypothetical protein-
LN360_RS24590 (5051146)5051146..5051436-291WP_000356395.1NadS family proteinAntitoxin
LN360_RS24595 (5051437)5051437..5051748-312WP_059332311.1hypothetical proteinToxin
LN360_RS24600 (5051977)5051977..5052885+909WP_001550353.1alpha/beta hydrolase-
LN360_RS24605 (5053053)5053053..5053967-915WP_109553727.1transposase-
LN360_RS24610 (5053980)5053980..5054867-888Protein_4814hypothetical protein-
LN360_RS24615 (5055283)5055283..5056224-942WP_001297068.1fatty acid biosynthesis protein FabY-
LN360_RS24620 (5056269)5056269..5056706-438WP_000560983.1D-aminoacyl-tRNA deacylase-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(36-85)


Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12212.25 Da        Isoelectric Point: 10.0241

>T224223 WP_059332311.1 NZ_CP086625:c5051748-5051437 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPHYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

>T224223 NZ_CP119754:c2309344-2309021 [Superficieibacter sp. HKU1]
ATGCATGTAATTTCACAAAAGAAACTTGCCCTTGCGGCAGAGAAGTACCCACAGTTCAGAGATGAGTTGATCGCAATGGG
AAAGATTATTGCTAAAGGGTATTTCCCTGGCCCTGATTCATTACGGCAAATTTATCCCACTCTGGATAATATTAAATATA
TTGATAAGTACTATGTTATTGATATAGCAAGAAACAGGCTACGAGTCATTGCAATTATCTTCTTCAGGACACAGAAATTT
TATGTTCGACATGTTTACACACATAAAGAGTACGATGAATTTGTGATGAAGTGCCGCACTAAAGGAAAAACCAAATGGCT
GTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 10.8907

>AT224223 WP_000356395.1 NZ_CP086625:c5051436-5051146 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp

>AT224223 NZ_CP119754:c2309030-2308614 [Superficieibacter sp. HKU1]
ATGGCTGTAGAAGAAGCATTAAAAGCAGCAGAAGCAATAAAACGAGCAATCCCCCTCCTGGTCGGTAGTACACGATGTGA
GGACTATGATAATGCTCTGAGTCTGGTTGAATATTGGCTCCTGCACGACCCGGAAAACCCGCTGCTTGAGTTGGTAGCCG
CAAAAATTGCGGCATATGAAGCAACATTACCTGAAGTGGCTGCATTCAGAAAAGCGAGCGCTGAAGCCCCTTCCGCACTC
GCTACGCTACGGATCCTCATCGACCAACATAATCTGACGCTTTCAGATTTTAAAGATGAAATCGGCAGCAAATCTATGGT
ATCGCGCGTATTAAACGGTGAACGCCAACTTACCCTCGCACACATAAAAAAACTTGCTGCACGGTTTGGTGTATCCCCAA
CGCTATTCCTCGACTAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A4Y9BEM6


Antitoxin

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Source
ID
Structure
No matching records found

References