Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HTH(antitoxin) |
Location | 5051146..5051748 | Replicon | chromosome |
Accession | NZ_CP086625 | ||
Organism | Escherichia coli strain RIVM_C037166 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A4Y9BEM6 |
Locus tag | LN360_RS24595 | Protein ID | WP_059332311.1 |
Coordinates | 5051437..5051748 (-) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | LN360_RS24590 | Protein ID | WP_000356395.1 |
Coordinates | 5051146..5051436 (-) | Length | 97 a.a. |
Genomic Context
Location: 5046770..5047672 (903 bp)
Type: Others
Protein ID: WP_000331377.1
Type: Others
Protein ID: WP_000331377.1
Location: 5047669..5048304 (636 bp)
Type: Others
Protein ID: WP_000829013.1
Type: Others
Protein ID: WP_000829013.1
Location: 5048301..5049230 (930 bp)
Type: Others
Protein ID: WP_000027720.1
Type: Others
Protein ID: WP_000027720.1
Location: 5051977..5052885 (909 bp)
Type: Others
Protein ID: WP_001550353.1
Type: Others
Protein ID: WP_001550353.1
Location: 5049412..5049654 (243 bp)
Type: Others
Protein ID: WP_001309881.1
Type: Others
Protein ID: WP_001309881.1
Location: 5049873..5050091 (219 bp)
Type: Others
Protein ID: WP_001295676.1
Type: Others
Protein ID: WP_001295676.1
Location: 5050510..5050788 (279 bp)
Type: Others
Protein ID: WP_001315112.1
Type: Others
Protein ID: WP_001315112.1
Location: 5050840..5051061 (222 bp)
Type: Others
Protein ID: WP_001550354.1
Type: Others
Protein ID: WP_001550354.1
Location: 5051146..5051436 (291 bp)
Type: Antitoxin
Protein ID: WP_000356395.1
Type: Antitoxin
Protein ID: WP_000356395.1
Location: 5051437..5051748 (312 bp)
Type: Toxin
Protein ID: WP_059332311.1
Type: Toxin
Protein ID: WP_059332311.1
Location: 5053053..5053967 (915 bp)
Type: Others
Protein ID: WP_109553727.1
Type: Others
Protein ID: WP_109553727.1
Location: 5053980..5054867 (888 bp)
Type: Others
Protein ID: Protein_4814
Type: Others
Protein ID: Protein_4814
Location: 5055283..5056224 (942 bp)
Type: Others
Protein ID: WP_001297068.1
Type: Others
Protein ID: WP_001297068.1
Location: 5056269..5056706 (438 bp)
Type: Others
Protein ID: WP_000560983.1
Type: Others
Protein ID: WP_000560983.1
Loading, please wait
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LN360_RS24555 (5046770) | 5046770..5047672 | + | 903 | WP_000331377.1 | formate dehydrogenase O subunit beta | - |
LN360_RS24560 (5047669) | 5047669..5048304 | + | 636 | WP_000829013.1 | formate dehydrogenase cytochrome b556 subunit | - |
LN360_RS24565 (5048301) | 5048301..5049230 | + | 930 | WP_000027720.1 | formate dehydrogenase accessory protein FdhE | - |
LN360_RS24570 (5049412) | 5049412..5049654 | - | 243 | WP_001309881.1 | CopG family transcriptional regulator | - |
LN360_RS24575 (5049873) | 5049873..5050091 | - | 219 | WP_001295676.1 | CopG family transcriptional regulator | - |
LN360_RS24580 (5050510) | 5050510..5050788 | - | 279 | WP_001315112.1 | hypothetical protein | - |
LN360_RS24585 (5050840) | 5050840..5051061 | - | 222 | WP_001550354.1 | hypothetical protein | - |
LN360_RS24590 (5051146) | 5051146..5051436 | - | 291 | WP_000356395.1 | NadS family protein | Antitoxin |
LN360_RS24595 (5051437) | 5051437..5051748 | - | 312 | WP_059332311.1 | hypothetical protein | Toxin |
LN360_RS24600 (5051977) | 5051977..5052885 | + | 909 | WP_001550353.1 | alpha/beta hydrolase | - |
LN360_RS24605 (5053053) | 5053053..5053967 | - | 915 | WP_109553727.1 | transposase | - |
LN360_RS24610 (5053980) | 5053980..5054867 | - | 888 | Protein_4814 | hypothetical protein | - |
LN360_RS24615 (5055283) | 5055283..5056224 | - | 942 | WP_001297068.1 | fatty acid biosynthesis protein FabY | - |
LN360_RS24620 (5056269) | 5056269..5056706 | - | 438 | WP_000560983.1 | D-aminoacyl-tRNA deacylase | - |
Associated MGEs
Loading, please wait
MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12212.25 Da Isoelectric Point: 10.0241
>T224223 WP_059332311.1 NZ_CP086625:c5051748-5051437 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPHYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPHYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW
Download Length: 312 bp
>T224223 NZ_CP119754:c2309344-2309021 [Superficieibacter sp. HKU1]
ATGCATGTAATTTCACAAAAGAAACTTGCCCTTGCGGCAGAGAAGTACCCACAGTTCAGAGATGAGTTGATCGCAATGGG
AAAGATTATTGCTAAAGGGTATTTCCCTGGCCCTGATTCATTACGGCAAATTTATCCCACTCTGGATAATATTAAATATA
TTGATAAGTACTATGTTATTGATATAGCAAGAAACAGGCTACGAGTCATTGCAATTATCTTCTTCAGGACACAGAAATTT
TATGTTCGACATGTTTACACACATAAAGAGTACGATGAATTTGTGATGAAGTGCCGCACTAAAGGAAAAACCAAATGGCT
GTAG
ATGCATGTAATTTCACAAAAGAAACTTGCCCTTGCGGCAGAGAAGTACCCACAGTTCAGAGATGAGTTGATCGCAATGGG
AAAGATTATTGCTAAAGGGTATTTCCCTGGCCCTGATTCATTACGGCAAATTTATCCCACTCTGGATAATATTAAATATA
TTGATAAGTACTATGTTATTGATATAGCAAGAAACAGGCTACGAGTCATTGCAATTATCTTCTTCAGGACACAGAAATTT
TATGTTCGACATGTTTACACACATAAAGAGTACGATGAATTTGTGATGAAGTGCCGCACTAAAGGAAAAACCAAATGGCT
GTAG
Antitoxin
Download Length: 97 a.a. Molecular weight: 10869.46 Da Isoelectric Point: 10.8907
>AT224223 WP_000356395.1 NZ_CP086625:c5051436-5051146 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR
Download Length: 291 bp
>AT224223 NZ_CP119754:c2309030-2308614 [Superficieibacter sp. HKU1]
ATGGCTGTAGAAGAAGCATTAAAAGCAGCAGAAGCAATAAAACGAGCAATCCCCCTCCTGGTCGGTAGTACACGATGTGA
GGACTATGATAATGCTCTGAGTCTGGTTGAATATTGGCTCCTGCACGACCCGGAAAACCCGCTGCTTGAGTTGGTAGCCG
CAAAAATTGCGGCATATGAAGCAACATTACCTGAAGTGGCTGCATTCAGAAAAGCGAGCGCTGAAGCCCCTTCCGCACTC
GCTACGCTACGGATCCTCATCGACCAACATAATCTGACGCTTTCAGATTTTAAAGATGAAATCGGCAGCAAATCTATGGT
ATCGCGCGTATTAAACGGTGAACGCCAACTTACCCTCGCACACATAAAAAAACTTGCTGCACGGTTTGGTGTATCCCCAA
CGCTATTCCTCGACTAA
ATGGCTGTAGAAGAAGCATTAAAAGCAGCAGAAGCAATAAAACGAGCAATCCCCCTCCTGGTCGGTAGTACACGATGTGA
GGACTATGATAATGCTCTGAGTCTGGTTGAATATTGGCTCCTGCACGACCCGGAAAACCCGCTGCTTGAGTTGGTAGCCG
CAAAAATTGCGGCATATGAAGCAACATTACCTGAAGTGGCTGCATTCAGAAAAGCGAGCGCTGAAGCCCCTTCCGCACTC
GCTACGCTACGGATCCTCATCGACCAACATAATCTGACGCTTTCAGATTTTAAAGATGAAATCGGCAGCAAATCTATGGT
ATCGCGCGTATTAAACGGTGAACGCCAACTTACCCTCGCACACATAAAAAAACTTGCTGCACGGTTTGGTGTATCCCCAA
CGCTATTCCTCGACTAA
Structures
Toxin
Loading, please wait
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A4Y9BEM6 |
Antitoxin
Loading, please wait
Source | ID | Structure |
---|---|---|
No matching records found |