Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1202014..1202591 Replicon chromosome
Accession NZ_CP086610
Organism Shinella zoogloeoides strain ATCC 19623

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K8M09_RS06040 Protein ID WP_160784795.1
Coordinates 1202014..1202292 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K8M09_RS06045 Protein ID WP_160784794.1
Coordinates 1202304..1202591 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8M09_RS06015 (K8M09_06010) 1198321..1199274 - 954 WP_160784799.1 agmatinase -
K8M09_RS06020 (K8M09_06015) 1199413..1199889 - 477 WP_160784798.1 30S ribosomal protein S9 -
K8M09_RS06025 (K8M09_06020) 1199892..1200356 - 465 WP_119258742.1 50S ribosomal protein L13 -
K8M09_RS06030 (K8M09_06025) 1200586..1201017 - 432 WP_160784797.1 PaaI family thioesterase -
K8M09_RS06035 (K8M09_06030) 1201153..1201968 + 816 WP_160784796.1 enoyl-CoA hydratase -
K8M09_RS06040 (K8M09_06035) 1202014..1202292 + 279 WP_160784795.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K8M09_RS06045 (K8M09_06040) 1202304..1202591 + 288 WP_160784794.1 HigA family addiction module antitoxin Antitoxin
K8M09_RS06050 (K8M09_06045) 1202596..1203432 - 837 WP_160784793.1 EamA family transporter -
K8M09_RS06055 (K8M09_06050) 1203679..1204116 + 438 WP_160784792.1 CoA-binding protein -
K8M09_RS06060 (K8M09_06055) 1204180..1204608 + 429 WP_160784791.1 CoA-binding protein -
K8M09_RS06065 (K8M09_06060) 1204725..1206008 + 1284 WP_160784790.1 O-acetylhomoserine aminocarboxypropyltransferase -
K8M09_RS06070 (K8M09_06065) 1206065..1206409 + 345 WP_160784789.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(7-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(7-64)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10298.73 Da        Isoelectric Point: 8.9791

>T224015 WP_160784795.1 NZ_CP086610:1202014-1202292 [Shinella zoogloeoides]
MIKSIADTATRQFIEAGKSRYSGLDPGKAMARLNVLNAARSLDDISPLRSIGLHKLSGDRKGQWAMTINGPWRLCFRFEN
GDAYDVEIVDYH

Download         Length: 279 bp

>T224015 NZ_CP119566:3522250-3522516 [Pararhizobium sp. T808]
TTGGCCTGGACGATTGAGATTACCGCCAGAGCACGGAAAAATATCAGCAGCCTCGACAAACAAGCCGCAAGCCGCATCCT
CTCGTTTCTCTCGGACAGGTTGGCTGCGTCTGACAACCCACGCCAACTCGGCAAACAATTGGCCGGCCCGCTCAAGCACT
ATTGGAGCTACCGGGTCGGCGACTACCGTCTGCTGTGCGAAATCAAAGATGATAGGTTGATTGTGCTGGTTCTCGAGGTT
GGAAATCGCCGGGACATCTACCGGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10339.83 Da        Isoelectric Point: 7.0124

>AT224015 WP_160784794.1 NZ_CP086610:1202304-1202591 [Shinella zoogloeoides]
MFEVHPGSILKEELEARQMSGNALALALRINSGRVSEILSGKRGVSADTALRLGRYFGNDPQFWLGLQAAYDLAVARRES
GERILLEVLPAQTAA

Download         Length: 288 bp

>AT224015 NZ_CP119566:3522039-3522266 [Pararhizobium sp. T808]
ATGACGCTGTCAATTCGCCTTTCTGACGCCGATGAAAAGCAGCTGGAACAGCTTGCCCGCGAAACAGGGCAAAGCAAGGA
ATTCCACGTTCACCAGTTCATCAGGCAAGGTCTTGAGGACATCGAAGACTACAATATCGCCGCAGAGATCGCCAAGCGCG
TCCGAAACGGCGAAGAAGCCGTTTACTCTTTGGCCGAGGTAAGGAAAGACCTTGGCCTGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References