Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 73864..74128 | Replicon | plasmid pEF45-3 |
| Accession | NZ_CP086607 | ||
| Organism | Escherichia fergusonii strain EF20JDJ4045 | ||
Toxin (Protein)
| Gene name | pndA | Uniprot ID | E6BRV3 |
| Locus tag | LNN29_RS24440 | Protein ID | WP_001303307.1 |
| Coordinates | 73976..74128 (+) | Length | 51 a.a. |
Antitoxin (RNA)
| Gene name | pndB | ||
| Locus tag | - | ||
| Coordinates | 73864..73926 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LNN29_RS24425 (69103) | 69103..71394 | - | 2292 | WP_001289276.1 | F-type conjugative transfer protein TrbC | - |
| LNN29_RS24430 (71387) | 71387..72457 | - | 1071 | WP_000151576.1 | IncI1-type conjugal transfer protein TrbB | - |
| LNN29_RS24435 (72476) | 72476..73684 | - | 1209 | WP_000121273.1 | IncI1-type conjugal transfer protein TrbA | - |
| - (73864) | 73864..73926 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (73864) | 73864..73926 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (73864) | 73864..73926 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (73864) | 73864..73926 | - | 63 | NuclAT_0 | - | Antitoxin |
| LNN29_RS24440 (73976) | 73976..74128 | + | 153 | WP_001303307.1 | Hok/Gef family protein | Toxin |
| LNN29_RS24445 (74200) | 74200..74451 | - | 252 | WP_001291965.1 | hypothetical protein | - |
| LNN29_RS25270 (74951) | 74951..75046 | + | 96 | WP_001303310.1 | DinQ-like type I toxin DqlB | - |
| LNN29_RS24455 (75111) | 75111..75248 | - | 138 | WP_047088497.1 | hypothetical protein | - |
| LNN29_RS24460 (75293) | 75293..76519 | - | 1227 | WP_024186316.1 | RNA-guided endonuclease TnpB family protein | - |
| LNN29_RS24465 (76578) | 76578..76982 | + | 405 | WP_001175009.1 | IS200/IS605 family transposase | - |
| LNN29_RS24470 (77314) | 77314..77523 | - | 210 | WP_032178830.1 | hemolysin expression modulator Hha | - |
| LNN29_RS24475 (77621) | 77621..78283 | - | 663 | WP_000644794.1 | plasmid IncI1-type surface exclusion protein ExcA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | iutA / iucD / iucC / iucB / iucA / fdeC | 1..101785 | 101785 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5817.21 Da Isoelectric Point: 8.7948
>T224006 WP_001303307.1 NZ_CP086607:73976-74128 [Escherichia fergusonii]
MPQRTFLMMLIVICVTILCFVWMVRDSLCVLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVICVTILCFVWMVRDSLCVLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T224006 NZ_CP119563:c1759471-1759190 [Rhodobacter capsulatus]
ATGATCCAGAGCACCAAGGGAAAGCTTGCCACAGATGCCGTCAATGGCCATTACGGCAAGGACTTCCCGAGCGATCTGGT
GAAGCGGACTCGCGTCCTGCTGTCGGCTCTGCACGCGGCGTCCGTGCTTGAAGACTTGCGCTTTCCGCCCGGGAACAACC
TGGAGGAGCTCAAGGGCGATCGGGCGGGGCAACACTCGGTGCGGATCAACAGGCAATGGCGCATTTGCTTTGTTTGGACC
GAAACCGGCCCGGCAGACATCGAGATTGCGGACTATCAGTGA
ATGATCCAGAGCACCAAGGGAAAGCTTGCCACAGATGCCGTCAATGGCCATTACGGCAAGGACTTCCCGAGCGATCTGGT
GAAGCGGACTCGCGTCCTGCTGTCGGCTCTGCACGCGGCGTCCGTGCTTGAAGACTTGCGCTTTCCGCCCGGGAACAACC
TGGAGGAGCTCAAGGGCGATCGGGCGGGGCAACACTCGGTGCGGATCAACAGGCAATGGCGCATTTGCTTTGTTTGGACC
GAAACCGGCCCGGCAGACATCGAGATTGCGGACTATCAGTGA
Antitoxin
Download Length: 63 bp
>AT224006 NZ_CP086607:c73926-73864 [Escherichia fergusonii]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
