Detailed information of TA system TA223997

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3880889..3881147
• Replicon: chromosome
• Accession: NZ_CP086604
• Organism: Escherichia fergusonii strain EF20JDJ4045

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: LNN29_RS18920
• Protein ID: WP_000809173.1
• Coordinates: 3880889..3881041 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3881090..3881147 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LNN29_RS18900	3875953..3876540	+	588	WP_046083027.1	molybdopterin adenylyltransferase	-
LNN29_RS18905	3876574..3877140	-	567	WP_000528529.1	acetate uptake transporter	-
LNN29_RS18910	3877648..3879564	+	1917	WP_000516135.1	molecular chaperone DnaK	-
LNN29_RS18915	3879653..3880783	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
LNN29_RS18920	3880889..3881041	-	153	WP_000809173.1	type I toxin-antitoxin system toxin MokC	Toxin
-	3881090..3881147	+	58	-	-	Antitoxin
LNN29_RS18925	3881582..3882748	+	1167	WP_000681374.1	Na+/H+ antiporter NhaA	-
LNN29_RS18930	3882816..3883715	+	900	WP_000019050.1	transcriptional activator NhaR	-
LNN29_RS18935	3883811..3884074	-	264	WP_001274021.1	30S ribosomal protein S20	-
LNN29_RS18940	3884177..3884395	+	219	WP_012599853.1	DUF2575 family protein	-
LNN29_RS18945	3884403..3885344	+	942	WP_000767324.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5487.54 Da
• Isoelectric Point: 7.1312

>T223997 WP_000809173.1 NZ_CP086604:c3881041-3880889 [Escherichia fergusonii]
MKQHKAMIVALIVICVTAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T223997 NZ_CP119540:4389755-4390399 [Providencia stuartii]
ATGGCGTATATGAACCTAAACCCAGAAAAAGCACTTATCTGGAGAATAACCCATCGTCAGAATATTCCTTGGCTTTTTGC
CAATGGCTTATATGCAGGAAATAGTGAACATTATTCACCTAATTGGGTGACTATTGGCAATACAGACCTGATTAACCGCC
GCAATCAACGTCATGTACCTATTCAGCCGAATGGGGTACTTAATGATTATGTACCTTTCTATTTCACCCCTTTCTCGCCA
ATGATGTATAATATTTATACAGGCCGTGGTGGGGTGCGAAAAGTTCCCAATGATGATATTATCATCTTGGTTTCCAGCAT
GTATAAAATAGCCGCTCTAAAGATACCTTTTGTTTTCACCGATCGTCATGCGTATCCTGTAACATCTCAGTTCTATAACC
AGCTAACAGATCTCGCGGAGATAGATTGGGCTTTACTACAGCAGCGCAATTTTCACCGTGACCCTGATGACCCTGAAAAA
GTTGAAAGGTATCAAGCAGAAGCGTTAATTTATAAACATGTTCCTATGGAAGCCCTATTAGGTGCTGTTTGTTACACAAA
AGAAACCCAGCTAGAACTTCAAGCAAAAGCCAGCCAACTTGAGATTCATTTAGATATCCATTGCATTCCAAACTGGTACT
TTTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT223997 NZ_CP086604:3881090-3881147 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin