Detailed information of TA system TA223972

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2954845..2955113
• Replicon: chromosome
• Accession: NZ_CP086592
• Organism: Enterococcus faecalis strain Fac74

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: LNB41_RS14400
• Protein ID: WP_080113450.1
• Coordinates: 2954845..2955009 (+)
• Length: 55 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2954918..2955113 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LNB41_RS14380	2950299..2950931	-	633	WP_002358972.1	RloB family protein	-
LNB41_RS14385	2950940..2952235	-	1296	WP_010820355.1	ATP-binding protein	-
LNB41_RS14390	2952697..2954313	+	1617	WP_010820356.1	phosphatase PAP2/LCP family protein	-
LNB41_RS14395	2954621..2954725	+	105	WP_023894767.1	putative holin-like toxin	-
LNB41_RS14400	2954845..2955009	+	165	WP_080113450.1	putative holin-like toxin	Toxin
-	2954918..2955113	-	196	-	-	Antitoxin
LNB41_RS14405	2955398..2959264	-	3867	WP_010820360.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-45)

Sequences

Toxin

Protein

• Length: 55 a.a.
• Molecular weight: 6080.21 Da
• Isoelectric Point: 8.5145

>T223972 WP_080113450.1 NZ_CP086592:2954845-2955009 [Enterococcus faecalis]
ISLKNTNKTIVYCTTYETIQTILGFGMFTIALIALIVKLLKEDNRNDRCLTLAS

Nucleotide

• Length: 165 bp

>T223972 NZ_CP119528:2662771-2663115 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTAGAAGAATATAATGTGGAGTTAGTTTTTACTACTTTAAACAAACGCGCATGTTTCGA
CCCTACTTACGGTATCATATTTGTAAATCAAAATTTAACACCATCAGAACAAGAAGAAGCAATATATCACGAGTTAAAGC
ATGTAAAAGACCATGTGGATATAATGGCATTGTATAAAATTCCTGTTTTTCGTTCTAAGATGGAAGCTGAAGCAGAACAA
TATATGTTTAGAAGCTTAATCGAAAAATATGAAGGACAATACAATTACTCAAATGTTATAGCTCATTACAACTTAAAAAT
GGGACAAGAAATTTATTTGAAGTAA

Antitoxin

Nucleotide

• Length: 196 bp

>AT223972 NZ_CP086592:c2955113-2954918 [Enterococcus faecalis]
TGTGCTGCAATAGAAACGAAAAGAGAGGTATGCTTCCAACATAGCTCTCTAATGTAGAACCGTTACTAACGGTGACAAAA
TTTTAAAGATTTTGAAATGACCGTCTAACTAGCCAAAGTTAAACAGCGGTCATTTCTGTTGTCTTCTTTAAGCAATTTCA
CAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Structures

Antitoxin