Detailed information of TA system TA223964

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2873103..2873365
• Replicon: chromosome
• Accession: NZ_CP086592
• Organism: Enterococcus faecalis strain Fac74

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: LNB41_RS14035
• Protein ID: WP_002392696.1
• Coordinates: 2873222..2873365 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2873103..2873289 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LNB41_RS14020	2868469..2869182	-	714	WP_010820328.1	trehalose operon repressor	-
LNB41_RS14025	2869444..2872188	+	2745	WP_229023937.1	glycosyl hydrolase family 65 protein	-
LNB41_RS14030	2872203..2872853	+	651	WP_002367457.1	beta-phosphoglucomutase	-
-	2873103..2873289	+	187	-	-	Antitoxin
LNB41_RS14035	2873222..2873365	-	144	WP_002392696.1	type I toxin-antitoxin system toxin PepG1	Toxin
LNB41_RS14040	2873597..2874568	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
LNB41_RS14045	2874743..2875180	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
LNB41_RS14050	2875313..2875867	-	555	WP_010820330.1	Maf family protein	-
LNB41_RS14055	2875892..2878024	-	2133	WP_010820331.1	DNA mismatch repair endonuclease MutL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T223964 WP_002392696.1 NZ_CP086592:c2873365-2873222 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

>T223964 NZ_CP119520:4168161-4168544 [Telluria mixta]
ATGAATGATGTCCTGGTCGATACCTCGGTATGGGTAGACCACATCCGCAATCGCAACGAGGATCTGGTCAGCCTGTTGAC
GCTGGACCGGGTCTTGTCCCATCCGTTGATCGTGACCGAGCTCGCGTGCGGCACGCCGCCGACGCCGCGGTCCCGTGCGC
TGGCAGATATCGCGACATTGCCTCAGGCGCGTCAGGCGGCGCTGGAAGAGGTCCGGGGTTTCATCGAGCGCGAGCAGTTG
TATGGTCTGGGATGCGGCGTGGTCGGCCTGGCTCTGCTGGCGTCGACGCTGCTCACGCCAGGAGCGCGCTTGTGGTCGCT
GGACAGGCGCCTGGCACAGTTGGCGCAACGGTTCGGCGCTGCTTTTCTGCCGGCGCTTCAATAG

Antitoxin

Nucleotide

• Length: 187 bp

>AT223964 NZ_CP086592:2873103-2873289 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGCG
CAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin