Detailed information of TA system TA223959

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2801474..2801958
• Replicon: chromosome
• Accession: NZ_CP086592
• Organism: Enterococcus faecalis strain Fac74

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: LNB41_RS13680
• Protein ID: WP_075551663.1
• Coordinates: 2801474..2801575 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2801749..2801958 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LNB41_RS13655	2796999..2797952	-	954	WP_010820307.1	siderophore ABC transporter substrate-binding protein	-
LNB41_RS13660	2797991..2798746	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
LNB41_RS13665	2798743..2799708	-	966	WP_002367415.1	iron chelate uptake ABC transporter family permease subunit	-
LNB41_RS13670	2799705..2800652	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
LNB41_RS13675	2800837..2801289	+	453	WP_002354958.1	YueI family protein	-
LNB41_RS13680	2801474..2801575	-	102	WP_075551663.1	putative holin-like toxin	Toxin
-	2801749..2801958	+	210	-	-	Antitoxin
LNB41_RS13685	2801907..2802008	-	102	WP_075551663.1	putative holin-like toxin	-
LNB41_RS13690	2802198..2804468	-	2271	WP_002370088.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
LNB41_RS13695	2804639..2805145	+	507	WP_010820308.1	cysteine hydrolase family protein	-
LNB41_RS13700	2805335..2806231	+	897	WP_002354953.1	YitT family protein	-
LNB41_RS13705	2806282..2806680	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3599.34 Da
• Isoelectric Point: 4.5869

>T223959 WP_075551663.1 NZ_CP086592:c2801575-2801474 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T223959 NZ_CP119416:c355118-354849 [Agrobacterium fabrum]
GTGATCTGGACAATTGAATATCACACGCTTGTGCAGAAAGAGATGCGCAAAATAAATCCGGAAGTGCGCCGGCGCATCCG
CAGTTTTCTCCATGAAAGGCTGGCCGCACTGGACGACCCGCGCCAGATCGGCGCTACACTGCAAGGTTCCGAACTCGGAA
ATTTCTGGCGTTACCGGGTGGGCGATTACCGCATCATCTGCGATATACAGGACCAAAAGCTGGTCGTTCTGGTGGTCGAA
ATCGGCCATCGCCGTGAAATTTACCGTTAG

Antitoxin

Nucleotide

• Length: 210 bp

>AT223959 NZ_CP086592:2801749-2801958 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACAC
CAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTT
ATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin