Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2480809..2481332 Replicon chromosome
Accession NZ_CP086574
Organism Staphylococcus argenteus strain RIVM_M046968

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag LK342_RS11965 Protein ID WP_047527363.1
Coordinates 2480809..2481075 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag LK342_RS11970 Protein ID WP_047431397.1
Coordinates 2481075..2481332 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK342_RS11945 (LK342_11945) 2476171..2477358 - 1188 WP_047527354.1 MFS transporter -
LK342_RS11950 (LK342_11950) 2477702..2478475 - 774 WP_000072156.1 iron export ABC transporter permease subunit FetB -
LK342_RS11955 (LK342_11955) 2478468..2479130 - 663 WP_047527359.1 ATP-binding cassette domain-containing protein -
LK342_RS11960 (LK342_11960) 2479378..2480454 - 1077 WP_047527361.1 M42 family metallopeptidase -
LK342_RS11965 (LK342_11965) 2480809..2481075 - 267 WP_047527363.1 Txe/YoeB family addiction module toxin Toxin
LK342_RS11970 (LK342_11970) 2481075..2481332 - 258 WP_047431397.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LK342_RS11975 (LK342_11975) 2481688..2482152 + 465 WP_047431401.1 DUF1307 domain-containing protein -
LK342_RS11980 (LK342_11980) 2482320..2483897 - 1578 WP_047527367.1 FMN-binding glutamate synthase family protein -
LK342_RS11985 (LK342_11985) 2484091..2484840 + 750 WP_047527368.1 CPBP family lipoprotein N-acylation protein LnsB -
LK342_RS11990 (LK342_11990) 2485067..2486260 - 1194 WP_000675397.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10592.38 Da        Isoelectric Point: 10.4663

>T223946 WP_047527363.1 NZ_CP086574:c2481075-2480809 [Staphylococcus argenteus]
MSNYTVKIKNSAKSDLKKIKNSYLKKSFLKIVETLKNDPYKITQSFEKLEPKYLVRYLRKINHKHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T223946 NZ_CP119408:3988803-3989021 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9760.71 Da        Isoelectric Point: 4.1232

>AT223946 WP_047431397.1 NZ_CP086574:c2481332-2481075 [Staphylococcus argenteus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLDDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT223946 NZ_CP119408:3988402-3988776 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAGGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References