223935

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2396676..2397193 Replicon chromosome
Accession NZ_CP086572
Organism Staphylococcus argenteus strain RIVM_M036020

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7U7PWL3
Locus tag LK336_RS11440 Protein ID WP_031787172.1
Coordinates 2396927..2397193 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7U7PWU0
Locus tag LK336_RS11435 Protein ID WP_031787173.1
Coordinates 2396676..2396927 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK336_RS11410 (2392377) 2392377..2393096 + 720 WP_000479573.1 amino acid ABC transporter permease -
LK336_RS11415 (2393093) 2393093..2393824 + 732 WP_000615469.1 amino acid ABC transporter ATP-binding protein -
LK336_RS11420 (2393919) 2393919..2395169 - 1251 WP_031787175.1 aminoacyltransferase -
LK336_RS11425 (2395423) 2395423..2395785 + 363 WP_031787174.1 DUF4467 domain-containing protein -
LK336_RS11430 (2395805) 2395805..2396404 + 600 WP_000162802.1 DsbA family protein -
LK336_RS11435 (2396676) 2396676..2396927 + 252 WP_031787173.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LK336_RS11440 (2396927) 2396927..2397193 + 267 WP_031787172.1 Txe/YoeB family addiction module toxin Toxin
LK336_RS11445 (2397490) 2397490..2399034 + 1545 WP_031787171.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
LK336_RS11450 (2399217) 2399217..2399684 + 468 WP_031787170.1 SRPBCC domain-containing protein -
LK336_RS11455 (2399768) 2399768..2399953 + 186 WP_000230291.1 hypothetical protein -
LK336_RS11460 (2400170) 2400170..2400994 + 825 WP_000572040.1 formate/nitrite transporter family protein -
LK336_RS11465 (2401227) 2401227..2401763 + 537 WP_031787169.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10511.99 Da        Isoelectric Point: 9.7791

>T223935 WP_031787172.1 NZ_CP086572:2396927-2397193 [Staphylococcus argenteus]
MARLNITFSPQAFEDYEYFQQNDKKMVKKINELLKSIDRNGALQGIGKPEKLKSNLFGYYSRRINHEHRLVYTVDDNHIK
IASCRYHY

Download         Length: 267 bp

>T223935 NZ_CP119404:c3639768-3639391 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGCACCGACCAGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATCAACAGTATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCGGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9395.56 Da        Isoelectric Point: 4.3558

>AT223935 WP_031787173.1 NZ_CP086572:2396676-2396927 [Staphylococcus argenteus]
MIVKNYSYARQNLKTLMTKVNDDSDVVTVTSTDDKNVVIMSEADYNSIIETLYLQQNPNNAEHLAQSIADLERGKMVTKE
IDV

Download         Length: 252 bp

>AT223935 NZ_CP119404:c3640189-3639815 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGAGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7PWL3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7PWU0

References