Detailed information of TA system TA223927

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 18792..19130
• Replicon: chromosome
• Accession: NZ_CP086572
• Organism: Staphylococcus argenteus strain RIVM_M036020

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: LK336_RS00105
• Protein ID: WP_011447039.1
• Coordinates: 18792..18968 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	18956..19130 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LK336_RS00085	14027..17812	+	3786	WP_031788239.1	phage tail spike protein	-
LK336_RS00090	17802..17954	+	153	WP_001153681.1	hypothetical protein	-
LK336_RS00095	18001..18288	+	288	WP_001040256.1	hypothetical protein	-
LK336_RS00100	18346..18642	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
LK336_RS00105	18792..18968	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	18956..19130	-	175	-	-	Antitoxin
LK336_RS00115	19180..19434	+	255	WP_000611512.1	phage holin	-
LK336_RS00120	19446..20201	+	756	WP_000861030.1	CHAP domain-containing protein	-
LK336_RS00125	20392..20883	+	492	WP_000920035.1	staphylokinase	-
LK336_RS00130	21534..21869	+	336	Protein_25	SH3 domain-containing protein	-
LK336_RS00135	22380..22730	+	351	WP_000702262.1	complement inhibitor SCIN-A	-
LK336_RS00140	22783..23043	-	261	WP_001791826.1	hypothetical protein	-
LK336_RS00145	23354..23533	-	180	WP_000669789.1	hypothetical protein	-
LK336_RS00150	23905..24102	-	198	WP_000591859.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / scn	1..22730	22729

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T223927 WP_011447039.1 NZ_CP086572:18792-18968 [Staphylococcus argenteus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T223927 NZ_CP119404:838685-839092 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT223927 NZ_CP086572:c19130-18956 [Staphylococcus argenteus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin