223924

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2353042..2353559 Replicon chromosome
Accession NZ_CP086570
Organism Staphylococcus argenteus strain RIVM_M020832

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7U7PWL3
Locus tag LK341_RS11120 Protein ID WP_031787172.1
Coordinates 2353293..2353559 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7U7PWU0
Locus tag LK341_RS11115 Protein ID WP_031787173.1
Coordinates 2353042..2353293 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK341_RS11090 (2348743) 2348743..2349462 + 720 WP_000479573.1 amino acid ABC transporter permease -
LK341_RS11095 (2349459) 2349459..2350190 + 732 WP_000615469.1 amino acid ABC transporter ATP-binding protein -
LK341_RS11100 (2350285) 2350285..2351535 - 1251 WP_031787175.1 aminoacyltransferase -
LK341_RS11105 (2351789) 2351789..2352151 + 363 WP_031787174.1 DUF4467 domain-containing protein -
LK341_RS11110 (2352171) 2352171..2352770 + 600 WP_000162802.1 DsbA family protein -
LK341_RS11115 (2353042) 2353042..2353293 + 252 WP_031787173.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LK341_RS11120 (2353293) 2353293..2353559 + 267 WP_031787172.1 Txe/YoeB family addiction module toxin Toxin
LK341_RS11125 (2353856) 2353856..2355400 + 1545 WP_031787171.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
LK341_RS11130 (2355583) 2355583..2356050 + 468 WP_031787170.1 SRPBCC domain-containing protein -
LK341_RS11135 (2356134) 2356134..2356319 + 186 WP_000230291.1 hypothetical protein -
LK341_RS11140 (2356536) 2356536..2357360 + 825 WP_000572040.1 formate/nitrite transporter family protein -
LK341_RS11145 (2357593) 2357593..2358129 + 537 WP_031787169.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10511.99 Da        Isoelectric Point: 9.7791

>T223924 WP_031787172.1 NZ_CP086570:2353293-2353559 [Staphylococcus argenteus]
MARLNITFSPQAFEDYEYFQQNDKKMVKKINELLKSIDRNGALQGIGKPEKLKSNLFGYYSRRINHEHRLVYTVDDNHIK
IASCRYHY

Download         Length: 267 bp

>T223924 NZ_CP119404:c586759-586295 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9395.56 Da        Isoelectric Point: 4.3558

>AT223924 WP_031787173.1 NZ_CP086570:2353042-2353293 [Staphylococcus argenteus]
MIVKNYSYARQNLKTLMTKVNDDSDVVTVTSTDDKNVVIMSEADYNSIIETLYLQQNPNNAEHLAQSIADLERGKMVTKE
IDV

Download         Length: 252 bp

>AT223924 NZ_CP119404:c587094-586759 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7PWL3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7PWU0

References