Detailed information of TA system TA223913

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2671670..2672007
• Replicon: chromosome
• Accession: NZ_CP086566
• Organism: Enterococcus faecalis strain E512-TC2

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: E2Z0W4
• Locus tag: LM512_RS12680
• Protein ID: WP_002381035.1
• Coordinates: 2671670..2671813 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2671745..2672007 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LM512_RS12660	2666790..2667005	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
LM512_RS12665	2667144..2668136	+	993	WP_002413308.1	biotin--[acetyl-CoA-carboxylase] ligase	-
LM512_RS12670	2668400..2669038	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
LM512_RS12675	2669724..2671340	+	1617	WP_014525060.1	phosphatase PAP2/LCP family protein	-
LM512_RS12680	2671670..2671813	+	144	WP_002381035.1	putative holin-like toxin	Toxin
-	2671745..2672007	-	263	-	-	Antitoxin
LM512_RS12685	2672008..2676699	-	4692	WP_010783624.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5202.20 Da
• Isoelectric Point: 10.0041

>T223913 WP_002381035.1 NZ_CP086566:2671670-2671813 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Nucleotide

• Length: 144 bp

>T223913 NZ_CP119402:c2412493-2412317 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Nucleotide

• Length: 263 bp

>AT223913 NZ_CP086566:c2672007-2671745 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTACA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATATCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A2Z6BWH2

Antitoxin