Detailed information of TA system TA223906

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2592642..2592905
• Replicon: chromosome
• Accession: NZ_CP086566
• Organism: Enterococcus faecalis strain E512-TC2

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: LM512_RS12340
• Protein ID: WP_002392696.1
• Coordinates: 2592762..2592905 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2592642..2592829 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LM512_RS12325	2588056..2590800	+	2745	WP_002406717.1	glycosyl hydrolase family 65 protein	-
LM512_RS12330	2590815..2591465	+	651	WP_002354875.1	beta-phosphoglucomutase	-
LM512_RS12335	2591928..2592521	+	594	WP_002389391.1	PBECR4 domain-containing protein	-
LM512_RS12340	2592762..2592905	-	144	WP_002392696.1	type I toxin-antitoxin system toxin PepG1	Toxin
LM512_RS13410	2593314..2593439	-	126	WP_002413415.1	hypothetical protein	-
LM512_RS12345	2593644..2593850	+	207	WP_224561207.1	CPBP family intramembrane metalloprotease	-
LM512_RS12350	2593903..2594874	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
LM512_RS12355	2595049..2595486	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
LM512_RS12360	2595619..2596173	-	555	WP_002354869.1	Maf family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T223906 WP_002392696.1 NZ_CP086566:c2592905-2592762 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

>T223906 NZ_CP119402:c586759-586295 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin

Nucleotide

• Length: 188 bp

>AT223906 NZ_CP086566:2592642-2592829 [Enterococcus faecalis]
TGCGCTATAATGAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACTTTTT
GAATTATTTAAAAATAACCGTACTCGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGT
GCAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin