Detailed information of TA system TA223902

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2520105..2520364
• Replicon: chromosome
• Accession: NZ_CP086566
• Organism: Enterococcus faecalis strain E512-TC2

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: LM512_RS11995
• Protein ID: WP_075551663.1
• Coordinates: 2520263..2520364 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2520105..2520314 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LM512_RS11965	2515355..2516308	-	954	WP_002354964.1	siderophore ABC transporter substrate-binding protein	-
LM512_RS11970	2516347..2517102	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
LM512_RS11975	2517099..2518064	-	966	WP_002354961.1	iron chelate uptake ABC transporter family permease subunit	-
LM512_RS11980	2518061..2519008	-	948	WP_002394759.1	iron chelate uptake ABC transporter family permease subunit	-
LM512_RS11985	2519193..2519645	+	453	WP_002354958.1	YueI family protein	-
LM512_RS11990	2519830..2519931	-	102	WP_075551663.1	putative holin-like toxin	-
-	2520105..2520314	+	210	-	-	Antitoxin
LM512_RS11995	2520263..2520364	-	102	WP_075551663.1	putative holin-like toxin	Toxin
LM512_RS12000	2520554..2522824	-	2271	WP_002354955.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
LM512_RS12005	2522995..2523495	+	501	WP_002354954.1	cysteine hydrolase family protein	-
LM512_RS12010	2523798..2524694	+	897	WP_002365354.1	YitT family protein	-
LM512_RS12015	2524745..2525143	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3599.34 Da
• Isoelectric Point: 4.5869

>T223902 WP_075551663.1 NZ_CP086566:c2520364-2520263 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T223902 NZ_CP119400:c4013589-4013212 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Nucleotide

• Length: 210 bp

>AT223902 NZ_CP086566:2520105-2520314 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACAC
CAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTT
ATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin