Detailed information of TA system TA223880

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2593011..2593274
• Replicon: chromosome
• Accession: NZ_CP086564
• Organism: Enterococcus faecalis strain E512-TC1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: LM511_RS12340
• Protein ID: WP_002392696.1
• Coordinates: 2593131..2593274 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2593011..2593198 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LM511_RS12325	2588425..2591169	+	2745	WP_002406717.1	glycosyl hydrolase family 65 protein	-
LM511_RS12330	2591184..2591834	+	651	WP_002354875.1	beta-phosphoglucomutase	-
LM511_RS12335	2592297..2592890	+	594	WP_002389391.1	PBECR4 domain-containing protein	-
-	2593011..2593198	+	188	-	-	Antitoxin
LM511_RS12340	2593131..2593274	-	144	WP_002392696.1	type I toxin-antitoxin system toxin PepG1	Toxin
LM511_RS13415	2593683..2593808	-	126	WP_002413415.1	hypothetical protein	-
LM511_RS12345	2594013..2594219	+	207	WP_224561207.1	CPBP family intramembrane metalloprotease	-
LM511_RS12350	2594272..2595243	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
LM511_RS12355	2595418..2595855	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
LM511_RS12360	2595988..2596542	-	555	WP_002354869.1	Maf family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T223880 WP_002392696.1 NZ_CP086564:c2593274-2593131 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

>T223880 NZ_CP086564:c2593274-2593131 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACGGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 188 bp

>AT223880 NZ_CP086564:2593011-2593198 [Enterococcus faecalis]
TGCGCTATAATGAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACTTTTT
GAATTATTTAAAAATAACCGTACTCGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGT
GCAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin