Detailed information of TA system TA223875

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2520199..2520683
• Replicon: chromosome
• Accession: NZ_CP086564
• Organism: Enterococcus faecalis strain E512-TC1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: LM511_RS11990
• Protein ID: WP_075551663.1
• Coordinates: 2520199..2520300 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2520474..2520683 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LM511_RS11965	2515724..2516677	-	954	WP_002354964.1	siderophore ABC transporter substrate-binding protein	-
LM511_RS11970	2516716..2517471	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
LM511_RS11975	2517468..2518433	-	966	WP_002354961.1	iron chelate uptake ABC transporter family permease subunit	-
LM511_RS11980	2518430..2519377	-	948	WP_002394759.1	iron chelate uptake ABC transporter family permease subunit	-
LM511_RS11985	2519562..2520014	+	453	WP_002354958.1	YueI family protein	-
LM511_RS11990	2520199..2520300	-	102	WP_075551663.1	putative holin-like toxin	Toxin
-	2520474..2520683	+	210	-	-	Antitoxin
LM511_RS11995	2520632..2520733	-	102	WP_075551663.1	putative holin-like toxin	-
LM511_RS12000	2520923..2523193	-	2271	WP_002354955.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
LM511_RS12005	2523364..2523864	+	501	WP_002354954.1	cysteine hydrolase family protein	-
LM511_RS12010	2524167..2525063	+	897	WP_002365354.1	YitT family protein	-
LM511_RS12015	2525114..2525512	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3599.34 Da
• Isoelectric Point: 4.5869

>T223875 WP_075551663.1 NZ_CP086564:c2520300-2520199 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T223875 NZ_CP119371:6265188-6265439 [Pseudomonas sp. CBSPCAW29]
GTGTCGAAAAATGAAAAGCTGCTGGCCAAACTGCTCAATGAACAATCGGCTTTTACCTGGGCCGAACGGGTAACGCTGCT
GCGGCGACTGGGCTACACGCAAATCGAAGGCGCGGGTAGCCGAGTCAGGTTCGACATAGGCGACCCCAGTGCAATGATCA
CCTTGCACAAGCCTCACCCCGGCAACGAACTGAAACACTACATTCGGCGCCAAATCATCGAACAATTGAAATCAGGAGAA
CTGATTCAGTGA

Antitoxin

Nucleotide

• Length: 210 bp

>AT223875 NZ_CP086564:2520474-2520683 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACAC
CAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTT
ATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin