Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2538658..2539175 Replicon chromosome
Accession NC_009782
Organism Staphylococcus aureus subsp. aureus Mu3

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag SAHV_RS12965 Protein ID WP_000113265.1
Coordinates 2538658..2538924 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag SAHV_RS12970 Protein ID WP_000584499.1
Coordinates 2538924..2539175 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAHV_RS12940 2534086..2534622 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
SAHV_RS12945 2534856..2535680 - 825 WP_000572038.1 formate/nitrite transporter family protein -
SAHV_RS12950 2535897..2536079 - 183 WP_000230292.1 hypothetical protein -
SAHV_RS12955 2536163..2536630 - 468 WP_000153347.1 SRPBCC domain-containing protein -
SAHV_RS12960 2536816..2538363 - 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
SAHV_RS15280 2538552..2538623 - 72 Protein_2467 hypothetical protein -
SAHV_RS12965 2538658..2538924 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
SAHV_RS12970 2538924..2539175 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SAHV_RS12975 2539340..2539441 - 102 Protein_2470 hypothetical protein -
SAHV_RS12980 2539448..2540047 - 600 WP_000162810.1 DsbA family protein -
SAHV_RS12985 2540066..2540428 - 363 WP_000819843.1 DUF4467 domain-containing protein -
SAHV_RS12990 2540683..2541933 + 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
SAHV_RS12995 2542030..2542761 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
SAHV_RS13000 2542758..2543477 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T22387 WP_000113265.1 NC_009782:c2538924-2538658 [Staphylococcus aureus subsp. aureus Mu3]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T22387 NC_009782:c2538924-2538658 [Staphylococcus aureus subsp. aureus Mu3]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT22387 WP_000584499.1 NC_009782:c2539175-2538924 [Staphylococcus aureus subsp. aureus Mu3]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT22387 NC_009782:c2539175-2538924 [Staphylococcus aureus subsp. aureus Mu3]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7BWF


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References