Detailed information of TA system TA223862

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2799339..2799563
• Replicon: chromosome
• Accession: NZ_CP086560
• Organism: Enterococcus faecalis strain E509

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: LM510_RS13400
• Protein ID: WP_224561205.1
• Coordinates: 2799462..2799563 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2799339..2799517 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LM510_RS13375	2794986..2795939	-	954	WP_002359060.1	siderophore ABC transporter substrate-binding protein	-
LM510_RS13380	2795978..2796733	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
LM510_RS13385	2796730..2797695	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
LM510_RS13390	2797692..2798639	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
LM510_RS13395	2798824..2799276	+	453	WP_002378807.1	YueI family protein	-
-	2799339..2799517	+	179	-	-	Antitoxin
LM510_RS13400	2799462..2799563	-	102	WP_224561205.1	putative holin-like toxin	Toxin
LM510_RS13405	2799754..2802024	-	2271	WP_002378809.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
LM510_RS13410	2802195..2802701	+	507	WP_002378810.1	cysteine hydrolase family protein	-
LM510_RS13415	2802891..2803787	+	897	WP_002365354.1	YitT family protein	-
LM510_RS13420	2803838..2804236	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3629.37 Da
• Isoelectric Point: 4.5869

>T223862 WP_224561205.1 NZ_CP086560:c2799563-2799462 [Enterococcus faecalis]
MSIEATLELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T223862 NZ_CP119368:2005803-2005991 [Pseudomonas sp. CBSPCGW29]
GTGCAAAGCAGGCTATTGATCAAAGAGCTGCAAGAGGCAGGTTGGGTGCTGGATCGGGTGACGGGCAGCCATCATCTTTT
CACCCATCGCTATAACCCGTACACGATACCGGTGCCCCATCCCAAGAAGGACCTGCCGATGGGCACCGTGCGAAGTATCA
GGAAACGTGCCGGGCTGTTTTCGTTTTAG

Antitoxin

Nucleotide

• Length: 179 bp

>AT223862 NZ_CP086560:2799339-2799517 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCG
AAAATCAGTAGTGCAACAA

Structures

Antitoxin