Detailed information of TA system TA223849

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 32046..32382
• Replicon: chromosome
• Accession: NZ_CP086560
• Organism: Enterococcus faecalis strain E509

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A1J6YG70
• Locus tag: LM510_RS00145
• Protein ID: WP_002396786.1
• Coordinates: 32046..32189 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	32333..32382 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LM510_RS00125	27262..27477	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
LM510_RS00130	27616..28608	+	993	WP_002378862.1	biotin--[acetyl-CoA-carboxylase] ligase	-
LM510_RS00135	28775..29413	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
LM510_RS00140	30098..31714	+	1617	WP_002378864.1	phosphatase PAP2/LCP family protein	-
LM510_RS00145	32046..32189	+	144	WP_002396786.1	putative holin-like toxin	Toxin
-	32333..32382	+	50	-	-	Antitoxin
LM510_RS00150	32384..37075	-	4692	WP_002378865.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5203.19 Da
• Isoelectric Point: 8.6626

>T223849 WP_002396786.1 NZ_CP086560:32046-32189 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

>T223849 NZ_CP119344:c2125325-2124963 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Nucleotide

• Length: 50 bp

>AT223849 NZ_CP086560:32333-32382 [Enterococcus faecalis]
AATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATT

Structures

Toxin

• AlphaFold DB: A0A1J6YG70

Antitoxin