Detailed information of TA system TA223841

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2982186..2982537
• Replicon: chromosome
• Accession: NZ_CP086558
• Organism: Enterococcus faecalis strain E512

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: LM505_RS14685
• Protein ID: WP_080113450.1
• Coordinates: 2982373..2982537 (+)
• Length: 55 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2982186..2982371 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LM505_RS14660	2977828..2978460	-	633	WP_002358972.1	RloB family protein	-
LM505_RS14665	2978469..2979569	-	1101	WP_229022098.1	ATP-binding protein	-
LM505_RS14670	2979569..2979763	-	195	WP_229022099.1	hypothetical protein	-
LM505_RS14675	2980225..2981841	+	1617	WP_010820356.1	phosphatase PAP2/LCP family protein	-
LM505_RS14680	2982149..2982253	+	105	WP_023894767.1	putative holin-like toxin	-
-	2982186..2982371	-	186	-	-	Antitoxin
LM505_RS14685	2982373..2982537	+	165	WP_080113450.1	putative holin-like toxin	Toxin
LM505_RS14690	2982926..2986791	-	3866	Protein_2878	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-45)

Sequences

Toxin

Protein

• Length: 55 a.a.
• Molecular weight: 6080.21 Da
• Isoelectric Point: 8.5145

>T223841 WP_080113450.1 NZ_CP086558:2982373-2982537 [Enterococcus faecalis]
ISLKNTNKTIVYCTTYETIQTILGFGMFTIALIALIVKLLKEDNRNDRCLTLAS

Nucleotide

• Length: 165 bp

>T223841 NZ_CP119341:c2182397-2182035 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Nucleotide

• Length: 186 bp

>AT223841 NZ_CP086558:c2982371-2982186 [Enterococcus faecalis]
TGCTACAATAGAAACGAAAAGAGAGGTATGCTGTAACATACCTCTCTAATGTAGAACCGTTTAAGACGGTGACCATGTTA
ATTATTTAAAAATAACCGTACTCGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGCGC
AATCAAAGCAATGGTAAACATACCAA

Structures

Antitoxin