Detailed information of TA system TA223827

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2827275..2827498
• Replicon: chromosome
• Accession: NZ_CP086558
• Organism: Enterococcus faecalis strain E512

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: LM505_RS13950
• Protein ID: WP_075551663.1
• Coordinates: 2827397..2827498 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2827275..2827452 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LM505_RS13925	2822922..2823875	-	954	WP_010820307.1	siderophore ABC transporter substrate-binding protein	-
LM505_RS13930	2823914..2824669	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
LM505_RS13935	2824666..2825631	-	966	WP_002367415.1	iron chelate uptake ABC transporter family permease subunit	-
LM505_RS13940	2825628..2826575	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
LM505_RS13945	2826760..2827212	+	453	WP_002354958.1	YueI family protein	-
-	2827275..2827452	+	178	-	-	Antitoxin
LM505_RS13950	2827397..2827498	-	102	WP_075551663.1	putative holin-like toxin	Toxin
LM505_RS13955	2827830..2827931	-	102	WP_075551663.1	putative holin-like toxin	-
LM505_RS13960	2828121..2830391	-	2271	WP_002370088.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
LM505_RS13965	2830562..2831068	+	507	WP_010820308.1	cysteine hydrolase family protein	-
LM505_RS13970	2831258..2832154	+	897	WP_002354953.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3599.34 Da
• Isoelectric Point: 4.5869

>T223827 WP_075551663.1 NZ_CP086558:c2827498-2827397 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T223827 NZ_CP119338:c2486013-2485747 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Nucleotide

• Length: 178 bp

>AT223827 NZ_CP086558:2827275-2827452 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCTTTTATACCAGCGCCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTT
TTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGA
AAATCAGTAGTGCAACAA

Structures

Antitoxin