Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2827238..2827498 Replicon chromosome
Accession NZ_CP086558
Organism Enterococcus faecalis strain E512

Toxin (Protein)


Gene name txpA Uniprot ID -
Locus tag LM505_RS13950 Protein ID WP_075551663.1
Coordinates 2827397..2827498 (-) Length 34 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2827238..2827448 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LM505_RS13925 2822922..2823875 - 954 WP_010820307.1 siderophore ABC transporter substrate-binding protein -
LM505_RS13930 2823914..2824669 - 756 WP_002354962.1 ATP-binding cassette domain-containing protein -
LM505_RS13935 2824666..2825631 - 966 WP_002367415.1 iron chelate uptake ABC transporter family permease subunit -
LM505_RS13940 2825628..2826575 - 948 WP_002354960.1 iron chelate uptake ABC transporter family permease subunit -
LM505_RS13945 2826760..2827212 + 453 WP_002354958.1 YueI family protein -
- 2827238..2827448 + 211 - - Antitoxin
LM505_RS13950 2827397..2827498 - 102 WP_075551663.1 putative holin-like toxin Toxin
LM505_RS13955 2827830..2827931 - 102 WP_075551663.1 putative holin-like toxin -
LM505_RS13960 2828121..2830391 - 2271 WP_002370088.1 bifunctional glutamate--cysteine ligase/glutathione synthetase -
LM505_RS13965 2830562..2831068 + 507 WP_010820308.1 cysteine hydrolase family protein -
LM505_RS13970 2831258..2832154 + 897 WP_002354953.1 YitT family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-33)


Sequences


Toxin        


Download         Length: 34 a.a.        Molecular weight: 3599.34 Da        Isoelectric Point: 4.5869

>T223826 WP_075551663.1 NZ_CP086558:c2827498-2827397 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Download         Length: 102 bp

>T223826 NZ_CP119338:c2170528-2170319 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTAATTTAG

Antitoxin


Download         Length: 211 bp

>AT223826 NZ_CP086558:2827238-2827448 [Enterococcus faecalis]
TTCCATTTATAATAGAATTATGCTATTATGAAAATGAAAAAGAGAGGTATGCGGGTACATACCTCTCTTTTATACCAGCG
CCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGT
TATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References