Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) txpA-ratA/-
Location 501716..501944 Replicon chromosome
Accession NZ_CP086558
Organism Enterococcus faecalis strain E512

Toxin (Protein)


Gene name txpA Uniprot ID -
Locus tag LM505_RS02530 Protein ID WP_219843903.1
Coordinates 501716..501826 (+) Length 37 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 501809..501944 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LM505_RS02520 497148..499406 + 2259 WP_229022106.1 DNA helicase PcrA -
LM505_RS02525 499532..501562 + 2031 WP_081115754.1 NAD-dependent DNA ligase LigA -
LM505_RS02530 501716..501826 + 111 WP_219843903.1 putative holin-like toxin Toxin
- 501809..501944 - 136 - - Antitoxin
LM505_RS02535 502144..502449 + 306 WP_010819759.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
LM505_RS02540 502449..503918 + 1470 WP_010819760.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
LM505_RS02545 503918..505348 + 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
LM505_RS02550 505367..506455 + 1089 WP_002355572.1 diacylglycerol kinase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-33)


Sequences


Toxin        


Download         Length: 37 a.a.        Molecular weight: 3805.59 Da        Isoelectric Point: 5.9482

>T223821 WP_219843903.1 NZ_CP086558:501716-501826 [Enterococcus faecalis]
MSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Download         Length: 111 bp

>T223821 NZ_CP119334:1911282-1911560 [Vibrio alginolyticus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTGATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGAGATTTCGATGATTGTCTCTTACTGGGTCGAGGGCGATATCATCAGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 136 bp

>AT223821 NZ_CP086558:c501944-501809 [Enterococcus faecalis]
TGAAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACCAGTTATAAGAACTGGTGGCTTACTGAGTTATTGG
TTTTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References