Detailed information of TA system TA223818

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 501716..501942
• Replicon: chromosome
• Accession: NZ_CP086558
• Organism: Enterococcus faecalis strain E512

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: LM505_RS02530
• Protein ID: WP_219843903.1
• Coordinates: 501716..501826 (+)
• Length: 37 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	501737..501942 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LM505_RS02520	497148..499406	+	2259	WP_229022106.1	DNA helicase PcrA	-
LM505_RS02525	499532..501562	+	2031	WP_081115754.1	NAD-dependent DNA ligase LigA	-
LM505_RS02530	501716..501826	+	111	WP_219843903.1	putative holin-like toxin	Toxin
-	501737..501942	-	206	-	-	Antitoxin
LM505_RS02535	502144..502449	+	306	WP_010819759.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
LM505_RS02540	502449..503918	+	1470	WP_010819760.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	-
LM505_RS02545	503918..505348	+	1431	WP_002358703.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB	-
LM505_RS02550	505367..506455	+	1089	WP_002355572.1	diacylglycerol kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 37 a.a.
• Molecular weight: 3805.59 Da
• Isoelectric Point: 5.9482

>T223818 WP_219843903.1 NZ_CP086558:501716-501826 [Enterococcus faecalis]
MSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Nucleotide

• Length: 111 bp

>T223818 NZ_CP119333:59443-59592 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin

Nucleotide

• Length: 206 bp

>AT223818 NZ_CP086558:c501942-501737 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACCAGTTATAAGAACTGGTGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Structures

Antitoxin