Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1855467..1855969 | Replicon | chromosome |
| Accession | NZ_CP086556 | ||
| Organism | Escherichia coli strain ESY002 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | C5N07_RS08780 | Protein ID | WP_000767829.1 |
| Coordinates | 1855715..1855969 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | C5N07_RS08775 | Protein ID | WP_001259255.1 |
| Coordinates | 1855467..1855718 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C5N07_RS08750 (1850644) | 1850644..1851711 | - | 1068 | WP_046464156.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| C5N07_RS08755 (1851711) | 1851711..1852781 | - | 1071 | WP_000108945.1 | histidinol-phosphate transaminase | - |
| C5N07_RS08760 (1852778) | 1852778..1854082 | - | 1305 | WP_001446927.1 | histidinol dehydrogenase | - |
| C5N07_RS08765 (1854088) | 1854088..1854987 | - | 900 | WP_032329340.1 | ATP phosphoribosyltransferase | - |
| C5N07_RS08770 (1855133) | 1855133..1855183 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| C5N07_RS08775 (1855467) | 1855467..1855718 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| C5N07_RS08780 (1855715) | 1855715..1855969 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| C5N07_RS08785 (1856052) | 1856052..1856876 | + | 825 | WP_000754749.1 | SDR family oxidoreductase | - |
| C5N07_RS08790 (1856922) | 1856922..1857851 | + | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| C5N07_RS08795 (1858066) | 1858066..1858128 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| C5N07_RS08800 (1858118) | 1858118..1859476 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| C5N07_RS08805 (1859655) | 1859655..1860713 | + | 1059 | WP_000492321.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| C5N07_RS08810 (1860727) | 1860727..1860954 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T223798 WP_000767829.1 NZ_CP086556:1855715-1855969 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T223798 NZ_CP119319:3603529-3603870 [Kluyvera intermedia]
ATGTGGGATGTTGAAACAACGGATGTTTTCGACATGTGGTTTGAGGTGCAAACCGCAGCACTTAAGGAAGACATGCTCGC
CGCGATGCTCATTTTATCGGAATATGGCCCCCAACTGGGAAGGCCGTTTGCCGATACGGTGAATGGCTCTACTTTTTCGA
ATATGAAAGAGCTACGCATTCAGCATCAGGGCCATCCTATACGCGCTTTCTTTGTATTTGATCCTGCTCGCCATGGCATC
GTGCTATGTGCCGGGGATAAAACAGGCTTTAATGAAAAGAGATTCTATAAAGACATGATCAAACTCGCCGATGCCGAGTA
CCGTAAGCACCTTAATCAGTAA
ATGTGGGATGTTGAAACAACGGATGTTTTCGACATGTGGTTTGAGGTGCAAACCGCAGCACTTAAGGAAGACATGCTCGC
CGCGATGCTCATTTTATCGGAATATGGCCCCCAACTGGGAAGGCCGTTTGCCGATACGGTGAATGGCTCTACTTTTTCGA
ATATGAAAGAGCTACGCATTCAGCATCAGGGCCATCCTATACGCGCTTTCTTTGTATTTGATCCTGCTCGCCATGGCATC
GTGCTATGTGCCGGGGATAAAACAGGCTTTAATGAAAAGAGATTCTATAAAGACATGATCAAACTCGCCGATGCCGAGTA
CCGTAAGCACCTTAATCAGTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT223798 WP_001259255.1 NZ_CP086556:1855467-1855718 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT223798 NZ_CP119319:3603880-3604179 [Kluyvera intermedia]
ATGGCTACCCTTAAAGAACTCATGGCTAAACAGAGCCCAGAAAGCCAGGCACGTATTACGGAAAAAGTTGAGGTAATGCG
CCAGGTCATCGCTTTAAACATGTTAAGGGAAGAGCTAAACCTGTCTCAGGCTGAGGTGGCTGCGGCAATGGGCGTCAAAC
AACCCACCATTGCAAAAATGGAACAGGCAGATAACGACCCGCGCTTATCAACGCTTAAACGCTACGTGACGGCATTAGGT
GGGGAGTTAAGTATGGAAGTTAAGCTGCCGACGGGTAAGAGAGTGGCCTTTCATCTTTAG
ATGGCTACCCTTAAAGAACTCATGGCTAAACAGAGCCCAGAAAGCCAGGCACGTATTACGGAAAAAGTTGAGGTAATGCG
CCAGGTCATCGCTTTAAACATGTTAAGGGAAGAGCTAAACCTGTCTCAGGCTGAGGTGGCTGCGGCAATGGGCGTCAAAC
AACCCACCATTGCAAAAATGGAACAGGCAGATAACGACCCGCGCTTATCAACGCTTAAACGCTACGTGACGGCATTAGGT
GGGGAGTTAAGTATGGAAGTTAAGCTGCCGACGGGTAAGAGAGTGGCCTTTCATCTTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|