Detailed information of TA system TA022379

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2089345..2089652
• Replicon: chromosome
• Accession: NC_009782
• Organism: Staphylococcus aureus subsp. aureus Mu3

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: SAHV_RS15170
• Protein ID: WP_011447039.1
• Coordinates: 2089476..2089652 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2089345..2089484 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAHV_RS10490	2084912..2085091	+	180	WP_000669791.1	hypothetical protein	-
SAHV_RS10500	2085402..2085662	+	261	WP_001791826.1	hypothetical protein	-
SAHV_RS10505	2085714..2086064	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
SAHV_RS10510	2086575..2086910	-	336	Protein_1992	SH3 domain-containing protein	-
SAHV_RS10515	2087561..2088052	-	492	WP_000920038.1	staphylokinase	-
SAHV_RS10520	2088267..2088998	-	732	WP_000861035.1	CHAP domain-containing protein	-
SAHV_RS10525	2089010..2089264	-	255	WP_000611512.1	phage holin	-
SAHV_RS10530	2089316..2089423	+	108	WP_031762631.1	hypothetical protein	-
-	2089345..2089484	+	140	NuclAT_0	-	Antitoxin
-	2089345..2089484	+	140	NuclAT_0	-	Antitoxin
-	2089345..2089484	+	140	NuclAT_0	-	Antitoxin
-	2089345..2089484	+	140	NuclAT_0	-	Antitoxin
SAHV_RS15170	2089476..2089652	-	177	WP_011447039.1	putative holin-like toxin	Toxin
SAHV_RS10540	2089761..2090534	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
SAHV_RS10545	2090907..2091281	-	375	WP_000340977.1	hypothetical protein	-
SAHV_RS10550	2091337..2091624	-	288	WP_001262621.1	hypothetical protein	-
SAHV_RS10555	2091670..2091822	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / scn / sak / sea / hlb / sell / sec / tsst-1 / groEL	2082220..2152385	70165

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T22379 WP_011447039.1 NC_009782:c2089652-2089476 [Staphylococcus aureus subsp. aureus Mu3]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T22379 NC_009782:c2089652-2089476 [Staphylococcus aureus subsp. aureus Mu3]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT22379 NC_009782:2089345-2089484 [Staphylococcus aureus subsp. aureus Mu3]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin