Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 42120..42384 | Replicon | plasmid pEc-042-T0_2 |
| Accession | NZ_CP086546 | ||
| Organism | Escherichia coli strain Ec-042-T0 | ||
Toxin (Protein)
| Gene name | pndA | Uniprot ID | U9Z417 |
| Locus tag | LNN55_RS23190 | Protein ID | WP_001387489.1 |
| Coordinates | 42120..42272 (-) | Length | 51 a.a. |
Antitoxin (RNA)
| Gene name | pndB | ||
| Locus tag | - | ||
| Coordinates | 42324..42384 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LNN55_RS23155 (37685) | 37685..37801 | + | 117 | Protein_42 | IncI1-type conjugal transfer lipoprotein TraH | - |
| LNN55_RS23160 (37800) | 37800..39554 | + | 1755 | Protein_43 | DotA/TraY family protein | - |
| LNN55_RS23165 (39625) | 39625..40287 | + | 663 | WP_000644796.1 | plasmid IncI1-type surface exclusion protein ExcA | - |
| LNN55_RS23170 (40359) | 40359..40568 | - | 210 | WP_000062603.1 | HEAT repeat domain-containing protein | - |
| LNN55_RS23175 (40960) | 40960..41136 | + | 177 | WP_001054897.1 | hypothetical protein | - |
| LNN55_RS23580 (41201) | 41201..41296 | - | 96 | WP_000609148.1 | DinQ-like type I toxin DqlB | - |
| LNN55_RS23185 (41797) | 41797..42048 | + | 252 | WP_001291964.1 | hypothetical protein | - |
| LNN55_RS23190 (42120) | 42120..42272 | - | 153 | WP_001387489.1 | Hok/Gef family protein | Toxin |
| - (42324) | 42324..42384 | + | 61 | NuclAT_0 | - | Antitoxin |
| - (42324) | 42324..42384 | + | 61 | NuclAT_0 | - | Antitoxin |
| - (42324) | 42324..42384 | + | 61 | NuclAT_0 | - | Antitoxin |
| - (42324) | 42324..42384 | + | 61 | NuclAT_0 | - | Antitoxin |
| LNN55_RS23195 (42593) | 42593..42967 | + | 375 | WP_223349261.1 | hypothetical protein | - |
| LNN55_RS23200 (43120) | 43120..44277 | + | 1158 | Protein_51 | IS1380-like element ISEcp1 family transposase | - |
| LNN55_RS23205 (44333) | 44333..45030 | + | 698 | WP_095033700.1 | IS1-like element IS1B family transposase | - |
| LNN55_RS23210 (45041) | 45041..45349 | - | 309 | WP_039023235.1 | transcription termination/antitermination NusG family protein | - |
| LNN55_RS23215 (45791) | 45791..46078 | - | 288 | WP_000074855.1 | conjugal transfer protein TraA | - |
| LNN55_RS23220 (46116) | 46116..46274 | - | 159 | Protein_55 | ash family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | blaCMY-42 | - | 1..47185 | 47185 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5761.10 Da Isoelectric Point: 8.7948
>T223787 WP_001387489.1 NZ_CP086546:c42272-42120 [Escherichia coli]
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T223787 NZ_CP119297:c3998668-3997355 [Proteus mirabilis]
ATGGCGAGTCTTGATGTATATATGAATGAATACTATGTGGGTATCTTTACTAAAAAAAGCTCAGGTGCGCATTCATTCCA
ATATACTGAAGATTGGGTTAATCAACCAGGAAGTCGTCCCATCTCTCTATCGATGCCATTACAACTTCAAGAATATCAAG
GAGACTGTGTCTATAATTTCTTTGATAATCTATTACCTGATAATACTGAAATTAGAAATCGTATTGTGAGTCGCTATAAT
GCGAACTCAAATCAACCCTTTGACCTATTAGTGGCTATCGGTGCAGATACTGTTGGTGCATTAAGGTTACTTCCTAGTGG
CAGTACGCCTGCGAATATCAAAAAAATAGAATATCAAAAACTCAATGATATTGAGCTTGAAAAAATTCTACTAGGATATA
AATCCAATACTCCACTCGGTATGCTTAAAAAATATACTGATTTCAGAATTTCCATCGCTGGAGCACAAGAAAAAACGGCA
TTACTTTTAAAAGATAATGATTGGTGTGTGCCACATAATAACACACCAACTACCCATATTATTAAACTGCCAATTGGTGT
TATTGAAAGTCATTCTTATACAATGGATTTATCCAATAGTGTAGAAAATGAGTATCTTTGTACCTTAATTGCCAAAGAAT
TTGATCTTCCCGTCCCCCACTGCTCTATTATTAAAACAAAAAATGTTAAAGCGCTTGCTGTAGAACGTTTTGATAGAAAA
TATTCATCTGATAAATCGTGGATAATACGTTTACCTCAAGAAGATTTTTGCCAAATTTTAAATATACCTTCTGCGCTAAA
ATATGAAAATGAAGGAGGGCCTGGCATTATCGATATTATGAAATATTTACTTGGCTCATCAAATGCCGATCAAGATCGTT
TTCATTTTATGAAGGCACAAGTGCTATTTTGGCTTTTGGCTGCAACGGATGGACACGCAAAAAATTTTTCTGTTTTTATC
AACCAAGAAGGACGTTTCCATCTCACTCCTCTTTATGACATTATGTCCATCTATCCCAATTTCGGAGGACGAGGACTTAA
TCCACGAGATGCAAAACTTGCTATGGGATTAAAAGCAAGCCGAGGCAAAAAATACGCAATAGAACAAATTTTTCCTCGTC
ATTTCTACCAAACAGCTGAAGCTGTCGGTTTCGATCCTTCATTAATGAGCGATATTCTTCGTTATTTTTATCAAGAAATG
GACGATGTCATACAACGCGTAAAACAGCAATTACCCGAGGATTTCCCTTCTGAGATTAGCAATACAATATTAGATGGAAT
GAAAGCACGCGCTGTTAGATTAGCTAACATTTAG
ATGGCGAGTCTTGATGTATATATGAATGAATACTATGTGGGTATCTTTACTAAAAAAAGCTCAGGTGCGCATTCATTCCA
ATATACTGAAGATTGGGTTAATCAACCAGGAAGTCGTCCCATCTCTCTATCGATGCCATTACAACTTCAAGAATATCAAG
GAGACTGTGTCTATAATTTCTTTGATAATCTATTACCTGATAATACTGAAATTAGAAATCGTATTGTGAGTCGCTATAAT
GCGAACTCAAATCAACCCTTTGACCTATTAGTGGCTATCGGTGCAGATACTGTTGGTGCATTAAGGTTACTTCCTAGTGG
CAGTACGCCTGCGAATATCAAAAAAATAGAATATCAAAAACTCAATGATATTGAGCTTGAAAAAATTCTACTAGGATATA
AATCCAATACTCCACTCGGTATGCTTAAAAAATATACTGATTTCAGAATTTCCATCGCTGGAGCACAAGAAAAAACGGCA
TTACTTTTAAAAGATAATGATTGGTGTGTGCCACATAATAACACACCAACTACCCATATTATTAAACTGCCAATTGGTGT
TATTGAAAGTCATTCTTATACAATGGATTTATCCAATAGTGTAGAAAATGAGTATCTTTGTACCTTAATTGCCAAAGAAT
TTGATCTTCCCGTCCCCCACTGCTCTATTATTAAAACAAAAAATGTTAAAGCGCTTGCTGTAGAACGTTTTGATAGAAAA
TATTCATCTGATAAATCGTGGATAATACGTTTACCTCAAGAAGATTTTTGCCAAATTTTAAATATACCTTCTGCGCTAAA
ATATGAAAATGAAGGAGGGCCTGGCATTATCGATATTATGAAATATTTACTTGGCTCATCAAATGCCGATCAAGATCGTT
TTCATTTTATGAAGGCACAAGTGCTATTTTGGCTTTTGGCTGCAACGGATGGACACGCAAAAAATTTTTCTGTTTTTATC
AACCAAGAAGGACGTTTCCATCTCACTCCTCTTTATGACATTATGTCCATCTATCCCAATTTCGGAGGACGAGGACTTAA
TCCACGAGATGCAAAACTTGCTATGGGATTAAAAGCAAGCCGAGGCAAAAAATACGCAATAGAACAAATTTTTCCTCGTC
ATTTCTACCAAACAGCTGAAGCTGTCGGTTTCGATCCTTCATTAATGAGCGATATTCTTCGTTATTTTTATCAAGAAATG
GACGATGTCATACAACGCGTAAAACAGCAATTACCCGAGGATTTCCCTTCTGAGATTAGCAATACAATATTAGATGGAAT
GAAAGCACGCGCTGTTAGATTAGCTAACATTTAG
Antitoxin
Download Length: 61 bp
>AT223787 NZ_CP086546:42324-42384 [Escherichia coli]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
