Detailed information of TA system TA223784

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3885126..3885384
• Replicon: chromosome
• Accession: NZ_CP086544
• Organism: Escherichia coli strain Ec-042-T0

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: LNN55_RS18855
• Protein ID: WP_000809168.1
• Coordinates: 3885232..3885384 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3885126..3885183 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LNN55_RS18835	3880174..3881505	+	1332	Protein_3693	fimbria/pilus outer membrane usher protein	-
LNN55_RS18840	3881518..3882476	+	959	Protein_3694	fimbrial family protein	-
LNN55_RS18845	3882515..3883414	-	900	WP_001300855.1	transcriptional activator NhaR	-
LNN55_RS18850	3883480..3884646	-	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
-	3885126..3885183	-	58	-	-	Antitoxin
LNN55_RS18855	3885232..3885384	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
LNN55_RS18860	3885488..3886618	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
LNN55_RS18865	3886707..3888623	-	1917	WP_000516131.1	molecular chaperone DnaK	-
LNN55_RS18870	3889000..3889404	+	405	WP_000843559.1	DUF2541 family protein	-
LNN55_RS18875	3889430..3890143	+	714	WP_001102383.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T223784 WP_000809168.1 NZ_CP086544:3885232-3885384 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T223784 NZ_CP119297:3074157-3074726 [Proteus mirabilis]
ATGACAAACTATACTGTTTTGCTTGATGCTTGTGTCATGTATCCAGCCCCTCTTAGAAGTTATTTAATGTATCTTGCTAA
TACTGGTTTATTTAGAGCACGTTGGAGTAATCAGATCCATGATGAATGGATCACTAATTTATTAGTCAACAATCCAACAT
TAACAGCTGAGCGACTAATACGAACCAGAGATTTAATGAATGCACATGTTCCTGATTGTTTAGTAGAAGGCTACGAACCG
CTTATTTGTGGTTTAAAGCTACCTGATCCTAATGATCGTCATGTGCTAGCAGCAGCAATAAAAGGGCAGGCTCAAGCTAT
AATTACATTTAACTTAAAAGATTTTCCGCAAAAATACCTTAATTCTTTTGATATTTCAGCTATCCATCCTGATGAATTTT
TGAGTGACATGTTTGAATTAAATCCTAGTAGCTGTATTAAAGCGGCGCAACAACATAGACAAAGCCTAAAGAATCCACCA
ATGACCGTAGAGACCTTTTTAGGCTGTTTACAAAAGCAGAAATTACCCCAGTTTATTTCCCATTTACGGGCATTCCAGAT
ATTATTATAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT223784 NZ_CP086544:c3885183-3885126 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin