Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 767284..767977 Replicon chromosome
Accession NZ_CP086538
Organism Escherichia coli strain Ec-042-T5-MAC

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag LNN52_RS03745 Protein ID WP_000415585.1
Coordinates 767284..767580 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag LNN52_RS03750 Protein ID WP_000650107.1
Coordinates 767582..767977 (+) Length 132 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNN52_RS03710 (762418) 762418..762897 + 480 WP_000065332.1 Hcp family type VI secretion system effector -
LNN52_RS03715 (762900) 762900..763610 + 711 WP_000834030.1 hypothetical protein -
LNN52_RS03720 (763617) 763617..763949 + 333 WP_000914690.1 DUF2645 family protein -
LNN52_RS03725 (763995) 763995..765344 - 1350 WP_000673358.1 quorum sensing histidine kinase QseC -
LNN52_RS03730 (765341) 765341..766000 - 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
LNN52_RS03735 (766152) 766152..766544 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
LNN52_RS03740 (766597) 766597..767079 + 483 WP_000183505.1 GyrI-like domain-containing protein -
LNN52_RS03745 (767284) 767284..767580 + 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
LNN52_RS03750 (767582) 767582..767977 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
LNN52_RS03755 (768110) 768110..769717 + 1608 WP_001375094.1 ABC transporter substrate-binding protein -
LNN52_RS03760 (769855) 769855..772113 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-97)

Antitoxin

(3-47)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T223743 WP_000415585.1 NZ_CP086538:767284-767580 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T223743 NZ_CP119172:c1463352-1462576 [Streptococcus macedonicus]
ATGAGATTGGAAGAATTTAGTGAGGCTGAGTTTCAGAAGGCCTTGCAGCGAACCATTCGGGCTTTAACCCGAGGCAAAAC
GATTCCAGAACAACCAAAAGCCATCTTGCTTGGCGGGCAAAGCGGAGCAGGTAAGACGACTATTCATCGTATCAAGCAAA
AAGAATTTCAAGGCAATATCATTATCATCGATGGTGATAGCTACCGTTCTCAGCATCCCAATTATTTAGCCCTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAACATCTGGTTGACGAGCTCAGCAC
GCAGGGTTATCACTTGCTGATTGAGGGAACCTTGCGAACTACTCAAGTTCCTCGTAAGACTGCTCAATTACTCCGTTCTA
AAGGCTACCAAGTTTCCTTAGCTGTGATTGGCACCAAACCAGAGCTTTCTTATCTCAGCACCTTGATTCGTTACGAAGAA
CTTTATGCCATCAATCCCAATCAGGCCAGAGCAACCCCAAAAAAACACCATGATGGGATTGTAGAGAACTTGGTTGATAA
CCTAAAGGAGCTCGAAAGCGATAAACTCTTTGACCAAATTCAGATTTATCAAAGAGATAGAACTTGTATCTACGATTCTG
AAACTGATGAAGGCTCCGCGGCAGAAGTGCTACAAGAATGCCTCTTTGGAAAATGGAGCAAGATAGAGGAGGAGATGCTG
AGGGTGGGAGAAGGACGGATGAGGGAGATGAGTAAAAGTAATGGAAAAGATGCATAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT223743 WP_000650107.1 NZ_CP086538:767582-767977 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT223743 NZ_CP119172:c1463828-1463352 [Streptococcus macedonicus]
ATGATCGGAGACAATATAAAATCACTACGCCGAACACACGATTTAACACAGCCAGAATTTGCGAAAATGGTTGGAATTTC
CCGCAATAGCCTGAGTCGCTATGAAAATGGAACCAGTAAAGTTTCAACAGAACTCATTGACTGTATTTGTCAGAAATTTA
ATGTTTCTTATGTTGATATTGTCGGGGAGGACAAGATGCTAACACCTGTTGAAGATTACCAATTGACCTTAAAAATCGAG
ATCATTAAAGAACGTGGAGCAGCCATTTTATCAAAGCTTTATAGATACCAAGATAGTCAAGATATTGCTTTTGATGATGA
ATCGAATCCGTGGATTCTCATGAGTGATGACTTGGCCGAATTGATTAACACGAAAATTTATCTTGTCGATACTTTCGATG
AAATAGAGCGTTACAATGGCTATTTAGATGGTATTGAGCGGATGTTAGACATGGTGCATCATCGGGTGCTGGCATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB U9ZN09


Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References