Detailed information of TA system TA223732

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3885130..3885388
• Replicon: chromosome
• Accession: NZ_CP086532
• Organism: Escherichia coli strain Ec-042-T5-ESBL

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: LNN41_RS18840
• Protein ID: WP_000809168.1
• Coordinates: 3885236..3885388 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3885130..3885187 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LNN41_RS18820	3880178..3881509	+	1332	Protein_3689	fimbria/pilus outer membrane usher protein	-
LNN41_RS18825	3881522..3882480	+	959	Protein_3690	fimbrial family protein	-
LNN41_RS18830	3882519..3883418	-	900	WP_001300855.1	transcriptional activator NhaR	-
LNN41_RS18835	3883484..3884650	-	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
-	3885130..3885187	-	58	-	-	Antitoxin
LNN41_RS18840	3885236..3885388	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
LNN41_RS18845	3885492..3886622	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
LNN41_RS18850	3886711..3888627	-	1917	WP_000516131.1	molecular chaperone DnaK	-
LNN41_RS18855	3889004..3889408	+	405	WP_000843559.1	DUF2541 family protein	-
LNN41_RS18860	3889434..3890147	+	714	WP_001102383.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T223732 WP_000809168.1 NZ_CP086532:3885236-3885388 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T223732 NZ_CP119165:c370125-369808 [Citrobacter freundii]
ATGTTCACATTTATTGAGCTACAAGGATTTAGTAAACGCCGTCCGTTACTTTTGCCTGACGATGAGTTTCGCGCTTTTCA
AGAGGCGCTTATAGAGAACCCTGAGGCTGGAGATAATATCGCTGGTACAGGTGGATTCAGAAAAATTCGCTGGAGTCGCT
CTGGTATGGGCAAACGCAGCGGTATTAGGGTTATCTATTACAACGTGACGCGCAAAGGTCGAATCTATCTCGCTTTGCTC
TATCCTAAAAATGAACAGGATGATTTAACCGAAGAGCAAAAAAGAGTTTTAATGCACTTATCCAATATGCTGATTTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT223732 NZ_CP086532:c3885187-3885130 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin