Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 767296..767989 Replicon chromosome
Accession NZ_CP086526
Organism Escherichia coli strain Ec-042-T20-MAC

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag LNN58_RS03750 Protein ID WP_000415585.1
Coordinates 767296..767592 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag LNN58_RS03755 Protein ID WP_000650107.1
Coordinates 767594..767989 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNN58_RS03715 (762430) 762430..762909 + 480 WP_000065332.1 Hcp family type VI secretion system effector -
LNN58_RS03720 (762912) 762912..763622 + 711 WP_000834030.1 hypothetical protein -
LNN58_RS03725 (763629) 763629..763961 + 333 WP_000914690.1 DUF2645 family protein -
LNN58_RS03730 (764007) 764007..765356 - 1350 WP_000673358.1 quorum sensing histidine kinase QseC -
LNN58_RS03735 (765353) 765353..766012 - 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
LNN58_RS03740 (766164) 766164..766556 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
LNN58_RS03745 (766609) 766609..767091 + 483 WP_000183505.1 GyrI-like domain-containing protein -
LNN58_RS03750 (767296) 767296..767592 + 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
LNN58_RS03755 (767594) 767594..767989 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
LNN58_RS03760 (768122) 768122..769729 + 1608 WP_001375094.1 ABC transporter substrate-binding protein -
LNN58_RS03765 (769867) 769867..772125 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T223691 WP_000415585.1 NZ_CP086526:767296-767592 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T223691 NZ_CP119133:c6504899-6504642 [Streptomyces sp. FXJ1.172]
GTGAGGAGCGTCCACTTCGACCCGGCCGCATGGGAGGACTTCCTGTTCCGGCTCGGCTCGGACCGCGGCATGGCCCGCAG
GATCACACGGCTGATCGCTGAGGTCCAGCGCACCCCCTTCACCGGCATCGGCAAGCCGGAACCCCTGAAGAGCGACCTGT
CCGGCTACTGGTCACGCCGGATCGACGACGAGCACCGGCTCGTGTACCGGGTGAACGAGAAGGAAGTCAAGATCCTCAAG
GCCCGCTACCACTACTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT223691 WP_000650107.1 NZ_CP086526:767594-767989 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT223691 NZ_CP119133:c6505168-6504896 [Streptomyces sp. FXJ1.172]
ATGACCATAAGCGCCAGCGAGGCCCGCAAGGACCTCTTCCCGCTCATCAAGCGCGTCAACGACGACCACACTCCCGTGCG
TATCAGCTCCAAGAGCGGCGACGCGGTACTGATGTCCGCCGAGGACTACGACTCCTGGCAGGAGACCGTCTACCTGCTGC
GCTCTCCCGCCAACGCGCGCAGCCTCATGGAAGCCGTCGCACGGGACAGGGCCGGCGAGGCCGTGGTCACCAGGACCATG
GCAGAGCTGGAAGAGCTGGCGGGTGACGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References