Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1056888..1057535 Replicon chromosome
Accession NC_009778
Organism Cronobacter sakazakii ATCC BAA-894

Toxin (Protein)


Gene name higB Uniprot ID A0A6L3S314
Locus tag ESA_RS05015 Protein ID WP_012124279.1
Coordinates 1056888..1057235 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID V5TYW5
Locus tag ESA_RS05020 Protein ID WP_007776551.1
Coordinates 1057236..1057535 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ESA_RS04990 1051964..1052974 + 1011 WP_004387466.1 galactose/methyl galactoside ABC transporter permease MglC -
ESA_RS04995 1053690..1054403 - 714 WP_004387784.1 outer membrane permeability protein SanA -
ESA_RS05000 1054528..1055412 - 885 WP_012124277.1 cytidine deaminase -
ESA_RS05005 1055542..1056237 - 696 WP_007869369.1 CidB/LrgB family autolysis modulator -
ESA_RS05010 1056234..1056635 - 402 WP_007869367.1 CidA/LrgA family protein -
ESA_RS05015 1056888..1057235 + 348 WP_012124279.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ESA_RS05020 1057236..1057535 + 300 WP_007776551.1 XRE family transcriptional regulator Antitoxin
ESA_RS05025 1057606..1058538 + 933 WP_012124281.1 tRNA dihydrouridine(16) synthase DusC -
ESA_RS05030 1058541..1059464 - 924 WP_012124282.1 LysR family transcriptional regulator -
ESA_RS05035 1059537..1060496 + 960 WP_012124283.1 MBL fold metallo-hydrolase -
ESA_RS21595 1060533..1060616 - 84 WP_000691708.1 protein YohP -
ESA_RS05040 1060789..1061562 + 774 WP_012124284.1 SDR family oxidoreductase -
ESA_RS05045 1061559..1062125 - 567 WP_012124285.1 DedA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-83)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13397.61 Da        Isoelectric Point: 9.8777

>T22361 WP_012124279.1 NC_009778:1056888-1057235 [Cronobacter sakazakii ATCC BAA-894]
MWTIYLTHEFECWLARQPQPLQEDVLTALGLLKIKGPHLGCPYADTLKGSRQAGMKELRVQHAGRSIRAFYAFDPHRYAI
VLCAAQKKGDEKRFYRVILRVADKLFSHYLNHREV

Download         Length: 348 bp

>T22361 NC_009778:1056888-1057235 [Cronobacter sakazakii ATCC BAA-894]
ATGTGGACTATTTACCTTACTCACGAGTTTGAGTGCTGGCTCGCGAGACAGCCGCAGCCGTTGCAGGAAGATGTGCTGAC
CGCGCTGGGGCTTTTGAAAATCAAAGGTCCGCACCTCGGGTGCCCGTATGCCGATACGCTCAAAGGCTCGCGCCAGGCGG
GTATGAAGGAATTACGGGTTCAGCACGCCGGGCGGTCCATACGCGCCTTTTACGCTTTTGATCCGCACCGTTACGCCATT
GTGCTGTGCGCGGCACAGAAAAAGGGCGATGAAAAGCGGTTTTACCGGGTCATACTGCGCGTCGCTGACAAACTGTTTAG
CCACTATCTGAACCACCGGGAGGTATAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11035.67 Da        Isoelectric Point: 5.1667

>AT22361 WP_007776551.1 NC_009778:1057236-1057535 [Cronobacter sakazakii ATCC BAA-894]
MKTFDEVLAAQTPEARARIEEKTAQLLLETHLYALREALSVSQTEMARQMGIAQPSVAAIEQRGNEMKISTLKRYVEALG
GTVRLDVELPDGQRFGFTL

Download         Length: 300 bp

>AT22361 NC_009778:1057236-1057535 [Cronobacter sakazakii ATCC BAA-894]
ATGAAGACGTTTGATGAAGTGCTGGCGGCGCAGACCCCGGAGGCCCGCGCGCGTATCGAAGAGAAAACGGCGCAGCTGCT
GCTGGAAACCCATCTGTATGCGCTGCGCGAGGCGCTCAGCGTGTCGCAAACCGAGATGGCGCGCCAGATGGGTATCGCCC
AGCCGTCAGTCGCGGCTATCGAACAGCGCGGCAACGAGATGAAAATCTCAACGCTTAAGCGCTATGTCGAAGCCCTGGGC
GGTACGGTGCGGCTGGATGTCGAGCTGCCGGACGGCCAGCGTTTCGGTTTTACGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L3S314

Antitoxin

Source ID Structure
AlphaFold DB A0A2S9UA72

References