Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1907583..1908085 | Replicon | chromosome |
| Accession | NZ_CP086500 | ||
| Organism | Escherichia coli strain Ec-050-T5-MAC | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | LNN49_RS09120 | Protein ID | WP_000767829.1 |
| Coordinates | 1907831..1908085 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | LNN49_RS09115 | Protein ID | WP_001259255.1 |
| Coordinates | 1907583..1907834 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LNN49_RS09090 (1902760) | 1902760..1903827 | - | 1068 | WP_000080090.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| LNN49_RS09095 (1903827) | 1903827..1904897 | - | 1071 | WP_000108933.1 | histidinol-phosphate transaminase | - |
| LNN49_RS09100 (1904894) | 1904894..1906198 | - | 1305 | WP_074514295.1 | histidinol dehydrogenase | - |
| LNN49_RS09105 (1906204) | 1906204..1907103 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| LNN49_RS09110 (1907249) | 1907249..1907299 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| LNN49_RS09115 (1907583) | 1907583..1907834 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| LNN49_RS09120 (1907831) | 1907831..1908085 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| LNN49_RS09125 (1908168) | 1908168..1908992 | + | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| LNN49_RS09130 (1909038) | 1909038..1909967 | + | 930 | WP_000803366.1 | LysR substrate-binding domain-containing protein | - |
| LNN49_RS09135 (1910182) | 1910182..1910244 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| LNN49_RS09140 (1910234) | 1910234..1911592 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| LNN49_RS09145 (1911771) | 1911771..1912829 | + | 1059 | WP_087523589.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| LNN49_RS09150 (1912843) | 1912843..1913070 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T223584 WP_000767829.1 NZ_CP086500:1907831-1908085 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T223584 NZ_CP118976:863914-864276 [Staphylococcus succinus]
ATGATGAGAAGAGGCGACGTTTATTTAGCTGATTTATCACCAGTGCAAGGGTCTGAGCAAGGGGGAATTAGACCTGTCGT
GATTATACAAAACGATACTGGAAATAAATATAGTCCTACCGTAATTGTAGCAGCAATTACTGGTAGGATAAATAAAGCTA
AAATACCAACACATGTAGAAATAGAAAAAAGTAAGTATAAGCTAGATAAAGATTCTGTTATTTTGTTAGAACAAATTAGA
ACTTTAGATAAAAACAGACTGAAAGAAAAATTAACTTATCTCTCTGATGATAAAATGAGAGAAGTAAACAATGCTATTGA
CATAAGCTTAGGATTACATAGTGTTAGGACAAACAAATCCTAA
ATGATGAGAAGAGGCGACGTTTATTTAGCTGATTTATCACCAGTGCAAGGGTCTGAGCAAGGGGGAATTAGACCTGTCGT
GATTATACAAAACGATACTGGAAATAAATATAGTCCTACCGTAATTGTAGCAGCAATTACTGGTAGGATAAATAAAGCTA
AAATACCAACACATGTAGAAATAGAAAAAAGTAAGTATAAGCTAGATAAAGATTCTGTTATTTTGTTAGAACAAATTAGA
ACTTTAGATAAAAACAGACTGAAAGAAAAATTAACTTATCTCTCTGATGATAAAATGAGAGAAGTAAACAATGCTATTGA
CATAAGCTTAGGATTACATAGTGTTAGGACAAACAAATCCTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT223584 WP_001259255.1 NZ_CP086500:1907583-1907834 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT223584 NZ_CP118976:863747-863917 [Staphylococcus succinus]
ATGGTAAGTTTTACTCAAAGCAGAAATCACAGTATTGAACAATTACTAAAAGAAGGCTATTCTCAAATGGCCGACTTAAA
CCTCTCCCTTGCAGCAGAAGCATTTCCATTTGAATGTGAAGCTTGTGATTGCAACGAAGTCTACATCAGCTCTAAGAATA
ACAATGAATGA
ATGGTAAGTTTTACTCAAAGCAGAAATCACAGTATTGAACAATTACTAAAAGAAGGCTATTCTCAAATGGCCGACTTAAA
CCTCTCCCTTGCAGCAGAAGCATTTCCATTTGAATGTGAAGCTTGTGATTGCAACGAAGTCTACATCAGCTCTAAGAATA
ACAATGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|