Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 67924..68188 | Replicon | plasmid pEc-050-T5-ESBL_1 |
| Accession | NZ_CP086491 | ||
| Organism | Escherichia coli strain Ec-050-T5-ESBL | ||
Toxin (Protein)
| Gene name | pndA | Uniprot ID | E6BRV3 |
| Locus tag | LNN51_RS23670 | Protein ID | WP_001303307.1 |
| Coordinates | 68036..68188 (+) | Length | 51 a.a. |
Antitoxin (RNA)
| Gene name | pndB | ||
| Locus tag | - | ||
| Coordinates | 67924..67986 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LNN51_RS23655 (63163) | 63163..65454 | - | 2292 | WP_001289275.1 | F-type conjugative transfer protein TrbC | - |
| LNN51_RS23660 (65447) | 65447..66517 | - | 1071 | WP_000151576.1 | IncI1-type conjugal transfer protein TrbB | - |
| LNN51_RS23665 (66536) | 66536..67744 | - | 1209 | WP_000121273.1 | IncI1-type conjugal transfer protein TrbA | - |
| - (67924) | 67924..67986 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (67924) | 67924..67986 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (67924) | 67924..67986 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (67924) | 67924..67986 | - | 63 | NuclAT_0 | - | Antitoxin |
| LNN51_RS23670 (68036) | 68036..68188 | + | 153 | WP_001303307.1 | Hok/Gef family protein | Toxin |
| LNN51_RS23675 (68260) | 68260..68511 | - | 252 | WP_001291965.1 | hypothetical protein | - |
| LNN51_RS26370 (69011) | 69011..69106 | + | 96 | WP_001303310.1 | DinQ-like type I toxin DqlB | - |
| LNN51_RS23685 (69171) | 69171..69308 | - | 138 | WP_047088497.1 | hypothetical protein | - |
| LNN51_RS23690 (69353) | 69353..70579 | - | 1227 | WP_024186316.1 | RNA-guided endonuclease TnpB family protein | - |
| LNN51_RS23695 (70638) | 70638..71042 | + | 405 | WP_001175009.1 | IS200/IS605 family transposase | - |
| LNN51_RS23700 (71374) | 71374..71583 | - | 210 | WP_032178830.1 | hemolysin expression modulator Hha | - |
| LNN51_RS23705 (71681) | 71681..72343 | - | 663 | WP_000644794.1 | plasmid IncI1-type surface exclusion protein ExcA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | sul2 / floR / blaTEM-30 / sul1 / qacE / ant(3'')-Ia / dfrA1 | - | 1..115986 | 115986 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5817.21 Da Isoelectric Point: 8.7948
>T223562 WP_001303307.1 NZ_CP086491:68036-68188 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCVLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVICVTILCFVWMVRDSLCVLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T223562 NZ_CP118962:c2771238-2770897 [Enterococcus faecalis]
ATGAATGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGCAAAGAGAT
TCAGAAGAGACGGCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
CTTCCACCATTAAAAATATTCCCACTCGATATACGTTGCCCGATGACATAGAAACCCATGGGCAAGTAGTGATCTCACAA
CTGAAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG
ATGAATGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGCAAAGAGAT
TCAGAAGAGACGGCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
CTTCCACCATTAAAAATATTCCCACTCGATATACGTTGCCCGATGACATAGAAACCCATGGGCAAGTAGTGATCTCACAA
CTGAAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG
Antitoxin
Download Length: 63 bp
>AT223562 NZ_CP086491:c67986-67924 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
