Detailed information of TA system TA022350

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ-RelB
• Location: 2036049..2036492
• Replicon: chromosome
• Accession: NC_009719
• Organism: Parvibaculum lavamentivorans DS-1

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: -
• Locus tag: PLAV_RS09500
• Protein ID: WP_202943977.1
• Coordinates: 2036307..2036492 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: A7HUA7
• Locus tag: PLAV_RS09495
• Protein ID: WP_012110783.1
• Coordinates: 2036049..2036306 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PLAV_RS18905	2031209..2033440	+	2232	WP_049767751.1	EAL domain-containing protein	-
PLAV_RS09485	2033594..2034787	+	1194	WP_012110781.1	acyl-CoA dehydrogenase family protein	-
PLAV_RS09490	2034799..2035893	+	1095	WP_012110782.1	acyl-CoA/acyl-ACP dehydrogenase	-
PLAV_RS09495	2036049..2036306	+	258	WP_012110783.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
PLAV_RS09500	2036307..2036492	+	186	WP_202943977.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
PLAV_RS19790	2036437..2036580	+	144	WP_202944038.1	type II toxin-antitoxin system YafQ family toxin	-
PLAV_RS09505	2036647..2036934	+	288	WP_041536563.1	SemiSWEET transporter	-
PLAV_RS09510	2037024..2038118	+	1095	WP_012110786.1	zinc-binding dehydrogenase	-
PLAV_RS09515	2038209..2038811	-	603	WP_012110787.1	glutathione S-transferase N-terminal domain-containing protein	-
PLAV_RS09520	2038837..2039328	-	492	WP_012110789.1	hypothetical protein	-
PLAV_RS09525	2039331..2039840	-	510	WP_012110791.1	phage holin family protein	-
PLAV_RS09530	2039850..2040119	-	270	WP_041535929.1	DUF883 C-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (6-59)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-81)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7064.39 Da
• Isoelectric Point: 11.4154

>T22350 WP_202943977.1 NC_009719:2036307-2036492 [Parvibaculum lavamentivorans DS-1]
MLSPVRSTQFKRDVKRAEKRGKDLGKLKRLLALLIERQPLPSAYRDHPLKGKLERIQGCSH

Nucleotide

• Length: 186 bp

>T22350 NC_009719:2036307-2036492 [Parvibaculum lavamentivorans DS-1]
ATGCTGTCGCCCGTCCGTTCGACGCAATTCAAGCGTGACGTGAAGCGAGCGGAAAAGCGTGGCAAGGATCTCGGCAAGCT
GAAACGGTTGCTCGCATTGCTGATCGAACGGCAGCCTCTGCCTTCAGCCTATCGCGACCATCCGCTCAAAGGAAAACTGG
AGCGGATTCAGGGATGCTCACATTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9117.68 Da
• Isoelectric Point: 10.3670

>AT22350 WP_012110783.1 NC_009719:2036049-2036306 [Parvibaculum lavamentivorans DS-1]
MAADSVVRARIDSGTKKKAAAALDAMGLSISDAIRLLLLRVADEKRLPFDVKVPNATTAKAIEQLEKGKGKKFTSAKELF
DDMGL

Nucleotide

• Length: 258 bp

>AT22350 NC_009719:2036049-2036306 [Parvibaculum lavamentivorans DS-1]
ATGGCTGCCGACAGCGTCGTTCGCGCGCGTATCGATTCCGGAACCAAGAAGAAGGCCGCCGCTGCGCTCGACGCGATGGG
ACTGTCGATTTCAGATGCCATTCGCCTGCTGTTGCTACGGGTTGCCGACGAGAAGCGATTGCCTTTCGATGTGAAGGTGC
CGAACGCAACAACAGCCAAGGCGATTGAGCAGCTTGAAAAAGGCAAAGGCAAGAAGTTTACGTCCGCAAAGGAATTGTTC
GACGATATGGGGCTTTAG

Structures

Antitoxin

• AlphaFold DB: A7HUA7