Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 721533..722226 Replicon chromosome
Accession NZ_CP086480
Organism Escherichia coli strain Ec-050-T20-MAC

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag LNN46_RS03525 Protein ID WP_000415584.1
Coordinates 721533..721829 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag LNN46_RS03530 Protein ID WP_000650107.1
Coordinates 721831..722226 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNN46_RS03490 (716621) 716621..716935 - 315 WP_000958598.1 putative quinol monooxygenase -
LNN46_RS03495 (716966) 716966..717547 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
LNN46_RS03500 (717866) 717866..718198 + 333 WP_000917685.1 DUF2645 family protein -
LNN46_RS03505 (718244) 718244..719593 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
LNN46_RS03510 (719590) 719590..720249 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
LNN46_RS03515 (720401) 720401..720793 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
LNN46_RS03520 (720846) 720846..721328 + 483 WP_000183505.1 GyrI-like domain-containing protein -
LNN46_RS03525 (721533) 721533..721829 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
LNN46_RS03530 (721831) 721831..722226 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
LNN46_RS03535 (722359) 722359..723966 + 1608 WP_087523553.1 ABC transporter substrate-binding protein -
LNN46_RS03540 (724104) 724104..726362 + 2259 WP_032329482.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T223497 WP_000415584.1 NZ_CP086480:721533-721829 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T223497 NZ_CP118927:330566-330934 [Citrobacter koseri]
ATGACACTTCAATTTATCTCAGCGGAAGAGATAATCCGTTTTCATGACAAATTATTGAGCGTAACGCCCGGCGTTCCGGG
AATGCCGGATCCTGGGCGGGCTGAAGCGCTGTTGTACCGTGTTTTAAATAAATACGAATACGAAAGTATTACCGATGTCT
GGATCCTTGCGGCGATGCATCTACTCGCTATTTCTCGTGGACATATTTTTAACGATGGTAATAAGAGAACAGCATTGTTC
ATCACATTACTGTTTCTCAAACGTAACGGTATCTTTCTGGCTGCTAATCCCGATTATGTTGATATGACAGTCGAAGCTGC
CGCAGGACGTCTGTCGCTAGAGGAAATTGTACAGCGTTTGCGTCGGTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT223497 WP_000650107.1 NZ_CP086480:721831-722226 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT223497 NZ_CP118927:330348-330569 [Citrobacter koseri]
ATGCGTACAATGAACTATAGTGAGGTACGGCAGAACCTTGCCTCTGTGCTTGATTCTGCTGCCACGGGTACGCCGGTGAC
GATTACGCGTCGGGGGCATAAATCTGCGGTTATCATCAGCGCAGAAGAATTTGAACGTTATCAGACAGCAAAACTGGATG
CTGAATTTGATGCCATCATGGGCGTTCACGGCGACGAATTAAGGGAACTGGCCGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References