Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 655570..656297 | Replicon | chromosome |
Accession | NZ_CP086480 | ||
Organism | Escherichia coli strain Ec-050-T20-MAC |
Toxin (Protein)
Gene name | higB | Uniprot ID | U9ZMR4 |
Locus tag | LNN46_RS03205 | Protein ID | WP_000550189.1 |
Coordinates | 655570..655884 (+) | Length | 105 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | LNN46_RS03210 | Protein ID | WP_000560266.1 |
Coordinates | 655881..656297 (+) | Length | 139 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LNN46_RS03185 (651728) | 651728..652714 | - | 987 | WP_000617698.1 | Gfo/Idh/MocA family oxidoreductase | - |
LNN46_RS03190 (652793) | 652793..653485 | - | 693 | WP_000942548.1 | vancomycin high temperature exclusion protein | - |
LNN46_RS03195 (653562) | 653562..654065 | - | 504 | WP_001333820.1 | M48 family metallopeptidase | - |
LNN46_RS03200 (654150) | 654150..655286 | + | 1137 | WP_000018695.1 | 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG | - |
LNN46_RS03205 (655570) | 655570..655884 | + | 315 | WP_000550189.1 | type II toxin-antitoxin system toxin HigB | Toxin |
LNN46_RS03210 (655881) | 655881..656297 | + | 417 | WP_000560266.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
LNN46_RS03215 (656342) | 656342..658360 | - | 2019 | WP_000121435.1 | NADPH-dependent 2,4-dienoyl-CoA reductase | - |
LNN46_RS03220 (658786) | 658786..661137 | - | 2352 | WP_000695487.1 | alpha-glucosidase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 12103.10 Da Isoelectric Point: 10.0409
>T223496 WP_000550189.1 NZ_CP086480:655570-655884 [Escherichia coli]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK
Download Length: 315 bp
>T223496 NZ_CP118927:c75006-74629 [Citrobacter koseri]
ATGAAAACATTACCCGACACACACATACGGGAGGCATCGCACTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCGCGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AAGCGGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCAGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGCATCCGGAGGCGAAACGATGA
ATGAAAACATTACCCGACACACACATACGGGAGGCATCGCACTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCGCGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AAGCGGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCAGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGCATCCGGAGGCGAAACGATGA
Antitoxin
Download Length: 139 a.a. Molecular weight: 14995.42 Da Isoelectric Point: 4.4547
>AT223496 WP_000560266.1 NZ_CP086480:655881-656297 [Escherichia coli]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID
Download Length: 417 bp
>AT223496 NZ_CP118927:c75461-75096 [Citrobacter koseri]
GTGTCAGACACACTGCCCGGGACAACGTATCCCGACAACAACAACCGCCCCTGGTGGGGGCTACCCTGCACCGTGATGCC
CTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGTTCA
GCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGTGAA
CTCAGCCCTCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGACACCTTCGGCTCCTGTGG
TTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACAAAAACGTAA
GTGTCAGACACACTGCCCGGGACAACGTATCCCGACAACAACAACCGCCCCTGGTGGGGGCTACCCTGCACCGTGATGCC
CTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGTTCA
GCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGTGAA
CTCAGCCCTCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGACACCTTCGGCTCCTGTGG
TTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACAAAAACGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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