Detailed information of TA system TA022344

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 22104..22703
• Replicon: chromosome
• Accession: NC_009719
• Organism: Parvibaculum lavamentivorans DS-1

Toxin (Protein)

• Gene name: graT
• Uniprot ID: A7HP10
• Locus tag: PLAV_RS00110
• Protein ID: WP_011994934.1
• Coordinates: 22425..22703 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: PLAV_RS00105
• Protein ID: WP_011994933.1
• Coordinates: 22104..22400 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PLAV_RS00080	17438..17962	-	525	WP_202944013.1	SCO family protein	-
PLAV_RS18580	18219..18803	+	585	WP_011994929.1	ankyrin repeat domain-containing protein	-
PLAV_RS00090	18899..19969	+	1071	WP_011994930.1	MBL fold metallo-hydrolase	-
PLAV_RS00095	20131..21474	+	1344	WP_041536108.1	ActS/PrrB/RegB family redox-sensitive histidine kinase	-
PLAV_RS00100	21475..22101	+	627	WP_011994932.1	ActR/PrrA/RegA family redox response regulator transcription factor	-
PLAV_RS00105	22104..22400	-	297	WP_011994933.1	HigA family addiction module antidote protein	Antitoxin
PLAV_RS00110	22425..22703	-	279	WP_011994934.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PLAV_RS00115	22748..23200	-	453	WP_041536110.1	MmcB family DNA repair protein	-
PLAV_RS00120	23247..24128	-	882	WP_041535757.1	aminoglycoside phosphotransferase family protein	-
PLAV_RS00125	24241..25362	-	1122	WP_011994937.1	ferritin-like domain-containing protein	-
PLAV_RS00130	25618..26940	+	1323	WP_011994938.1	Hsp70 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Cro/C1-type helix-turn-helix domain (21-68)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10759.24 Da
• Isoelectric Point: 10.1496

>T22344 WP_011994934.1 NC_009719:c22703-22425 [Parvibaculum lavamentivorans DS-1]
VIGSFADKDTERLWGRQSVARFRAFERIALRKLAQLDAARSLEDLKYPPGNRLEALKGNRKGQMSLRINDQWRICFEWRE
GGPENVQIVDYH

Nucleotide

• Length: 279 bp

>T22344 NC_009719:c22703-22425 [Parvibaculum lavamentivorans DS-1]
GTGATAGGAAGCTTCGCGGACAAGGACACCGAGCGCCTGTGGGGACGGCAATCCGTCGCCCGCTTTCGCGCCTTCGAGCG
AATTGCGCTGCGGAAGCTGGCTCAGCTCGACGCAGCACGCTCCCTGGAAGATCTGAAATATCCGCCGGGGAACCGGCTGG
AGGCACTCAAGGGTAACCGCAAGGGCCAGATGTCGCTCCGCATCAACGATCAGTGGCGTATCTGCTTCGAATGGCGGGAA
GGCGGCCCGGAGAATGTCCAGATTGTCGATTATCACTGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10791.46 Da
• Isoelectric Point: 10.3437

>AT22344 WP_011994933.1 NC_009719:c22400-22104 [Parvibaculum lavamentivorans DS-1]
MTKIAPIHPGEVLAEDFMKPLGLSANALAQKLGVPANRISTIVAGRRDVSPDTALRLERAFGSSAEFWLNMQARYDLETA
RDRIDRKELASIKTIRAA

Nucleotide

• Length: 297 bp

>AT22344 NC_009719:c22400-22104 [Parvibaculum lavamentivorans DS-1]
ATGACCAAAATTGCACCCATTCATCCCGGCGAGGTGCTGGCGGAAGATTTCATGAAGCCGCTTGGGCTCAGCGCCAATGC
GCTGGCGCAGAAGCTCGGCGTGCCCGCGAACCGCATCAGCACCATCGTGGCGGGGCGGCGCGACGTATCGCCGGACACAG
CCTTGCGGCTCGAGCGGGCTTTCGGATCGTCAGCCGAATTCTGGCTCAACATGCAGGCGCGTTACGACCTCGAAACGGCC
CGCGACCGGATCGACAGGAAGGAACTTGCTTCCATCAAAACGATCAGGGCCGCCTGA

Structures

Toxin

• AlphaFold DB: A7HP10