Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mqsRA (relBE)/MqsR-MqsA |
| Location | 1071193..1071893 | Replicon | chromosome |
| Accession | NC_009708 | ||
| Organism | Yersinia pseudotuberculosis IP 31758 | ||
Toxin (Protein)
| Gene name | mqsR | Uniprot ID | A0A0U1R210 |
| Locus tag | YPSIP31758_RS05780 | Protein ID | WP_012104682.1 |
| Coordinates | 1071193..1071495 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | mqsA | Uniprot ID | Q666X1 |
| Locus tag | YPSIP31758_RS05785 | Protein ID | WP_002209924.1 |
| Coordinates | 1071495..1071893 (+) | Length | 133 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| YPSIP31758_RS05745 | 1066315..1067832 | + | 1518 | WP_002209930.1 | lysine--tRNA ligase | - |
| YPSIP31758_RS05755 | 1068265..1069479 | + | 1215 | WP_011192954.1 | tyrosine-type recombinase/integrase | - |
| YPSIP31758_RS05760 | 1069561..1069746 | - | 186 | WP_012104680.1 | hypothetical protein | - |
| YPSIP31758_RS05770 | 1070344..1070604 | + | 261 | WP_002214785.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| YPSIP31758_RS05775 | 1070667..1071029 | + | 363 | WP_011192920.1 | helix-turn-helix domain-containing protein | - |
| YPSIP31758_RS05780 | 1071193..1071495 | + | 303 | WP_012104682.1 | type II toxin-antitoxin system MqsR family toxin | Toxin |
| YPSIP31758_RS05785 | 1071495..1071893 | + | 399 | WP_002209924.1 | type II toxin-antitoxin system MqsA family antitoxin | Antitoxin |
| YPSIP31758_RS05790 | 1072293..1074584 | - | 2292 | WP_012104683.1 | toprim domain-containing protein | - |
| YPSIP31758_RS05795 | 1074884..1075210 | + | 327 | WP_002209922.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| YPSIP31758_RS24305 | 1075203..1075355 | + | 153 | WP_002209921.1 | hypothetical protein | - |
| YPSIP31758_RS05805 | 1075369..1075569 | - | 201 | WP_002209920.1 | AlpA family transcriptional regulator | - |
| YPSIP31758_RS05810 | 1075751..1076083 | - | 333 | WP_038835201.1 | hypothetical protein | - |
| YPSIP31758_RS05815 | 1076198..1076431 | - | 234 | Protein_867 | hypothetical protein | - |
| YPSIP31758_RS05820 | 1076444..1076809 | - | 366 | WP_002209919.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11587.52 Da Isoelectric Point: 8.5040
>T22331 WP_012104682.1 NC_009708:1071193-1071495 [Yersinia pseudotuberculosis IP 31758]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLRLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCG
RVYLKITVIDDVLIVSFKEI
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLRLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCG
RVYLKITVIDDVLIVSFKEI
Download Length: 303 bp
>T22331 NC_009708:1071193-1071495 [Yersinia pseudotuberculosis IP 31758]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCG
CCGATTTTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGT
AGAGTTTATTTGAAAATCACGGTTATCGATGATGTTTTGATTGTCTCGTTTAAGGAGATTTAA
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCG
CCGATTTTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGT
AGAGTTTATTTGAAAATCACGGTTATCGATGATGTTTTGATTGTCTCGTTTAAGGAGATTTAA
Antitoxin
Download Length: 133 a.a. Molecular weight: 14657.17 Da Isoelectric Point: 8.4923
>AT22331 WP_002209924.1 NC_009708:1071495-1071893 [Yersinia pseudotuberculosis IP 31758]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR
Download Length: 399 bp
>AT22331 NC_009708:1071495-1071893 [Yersinia pseudotuberculosis IP 31758]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0U1R210 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q666X1 |