Detailed information of TA system TA223248

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-RNAII/-
• Location: 2888310..2888647
• Replicon: chromosome
• Accession: NZ_CP086411
• Organism: Enterococcus faecalis strain R5

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: E2Z0W4
• Locus tag: LMJ46_RS14360
• Protein ID: WP_002381035.1
• Coordinates: 2888310..2888453 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	RNAII
Locus tag	-
Coordinates	2888385..2888647 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LMJ46_RS14340 (2884402)	2884402..2885040	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
LMJ46_RS14345 (2885726)	2885726..2887342	+	1617	WP_002389442.1	phosphatase PAP2/LCP family protein	-
LMJ46_RS14350 (2887671)	2887671..2887820	+	150	WP_002411240.1	type I toxin-antitoxin system toxin PepG1	-
- (2887753)	2887753..2887937	-	185	NuclAT_9	-	-
- (2887794)	2887794..2887937	-	144	NuclAT_11	-	-
LMJ46_RS14355 (2887939)	2887939..2888079	+	141	WP_073340360.1	putative holin-like toxin	-
- (2888012)	2888012..2888213	-	202	NuclAT_7	-	-
LMJ46_RS14360 (2888310)	2888310..2888453	+	144	WP_002381035.1	putative holin-like toxin	Toxin
- (2888597)	2888597..2888646	+	50	NuclAT_13	-	-
- (2888385)	2888385..2888647	-	263	NuclAT_10	-	Antitoxin
LMJ46_RS14365 (2888648)	2888648..2892475	-	3828	WP_002389430.1	WxL domain-containing protein	-
LMJ46_RS14370 (2892462)	2892462..2892824	-	363	WP_033781532.1	LPXTG cell wall anchor domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5202.20 Da
• Isoelectric Point: 10.0041

>T223248 WP_002381035.1 NZ_CP086411:2888310-2888453 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Nucleotide

• Length: 144 bp

>T223248 NZ_CP118603:c72732-72583 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin

Nucleotide

• Length: 263 bp

>AT223248 NZ_CP086411:c2888647-2888385 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTACA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATATCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A2Z6BWH2

Antitoxin