Detailed information of TA system TA223242

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2887939..2888213
• Replicon: chromosome
• Accession: NZ_CP086411
• Organism: Enterococcus faecalis strain R5

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A3N3Z2N6
• Locus tag: LMJ46_RS14355
• Protein ID: WP_073340360.1
• Coordinates: 2887939..2888079 (+)
• Length: 47 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2888012..2888213 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LMJ46_RS14335 (2883146)	2883146..2884138	+	993	WP_002389493.1	biotin--[acetyl-CoA-carboxylase] ligase	-
LMJ46_RS14340 (2884402)	2884402..2885040	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
LMJ46_RS14345 (2885726)	2885726..2887342	+	1617	WP_002389442.1	phosphatase PAP2/LCP family protein	-
LMJ46_RS14350 (2887671)	2887671..2887820	+	150	WP_002411240.1	type I toxin-antitoxin system toxin PepG1	-
- (2887753)	2887753..2887937	-	185	NuclAT_9	-	-
- (2887794)	2887794..2887937	-	144	NuclAT_11	-	-
LMJ46_RS14355 (2887939)	2887939..2888079	+	141	WP_073340360.1	putative holin-like toxin	Toxin
- (2888012)	2888012..2888213	-	202	NuclAT_7	-	Antitoxin
LMJ46_RS14360 (2888310)	2888310..2888453	+	144	WP_002381035.1	putative holin-like toxin	-
- (2888597)	2888597..2888646	+	50	NuclAT_13	-	-
- (2888385)	2888385..2888647	-	263	NuclAT_10	-	-
LMJ46_RS14365 (2888648)	2888648..2892475	-	3828	WP_002389430.1	WxL domain-containing protein	-
LMJ46_RS14370 (2892462)	2892462..2892824	-	363	WP_033781532.1	LPXTG cell wall anchor domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-46)

Sequences

Toxin

Protein

• Length: 47 a.a.
• Molecular weight: 5218.33 Da
• Isoelectric Point: 10.3265

>T223242 WP_073340360.1 NZ_CP086411:2887939-2888079 [Enterococcus faecalis]
ISLKNTNKNIVYCTTYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 141 bp

>T223242 NZ_CP118601:2886026-2886133 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 202 bp

>AT223242 NZ_CP086411:c2888213-2888012 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGATATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A0A3N3Z2N6

Antitoxin