Detailed information of TA system TA223232

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2804510..2804772
• Replicon: chromosome
• Accession: NZ_CP086411
• Organism: Enterococcus faecalis strain R5

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: LMJ46_RS13985
• Protein ID: WP_002367458.1
• Coordinates: 2804629..2804772 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2804510..2804696 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LMJ46_RS13970 (2799967)	2799967..2802711	+	2745	WP_002411259.1	glycosyl hydrolase family 65 protein	-
LMJ46_RS13975 (2802726)	2802726..2803376	+	651	WP_002389419.1	beta-phosphoglucomutase	-
LMJ46_RS13980 (2803796)	2803796..2804389	+	594	WP_002389391.1	PBECR4 domain-containing protein	-
- (2804510)	2804510..2804655	+	146	NuclAT_12	-	-
- (2804510)	2804510..2804696	+	187	NuclAT_8	-	Antitoxin
LMJ46_RS13985 (2804629)	2804629..2804772	-	144	WP_002367458.1	type I toxin-antitoxin system toxin PepG1	Toxin
LMJ46_RS13990 (2805004)	2805004..2805975	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
LMJ46_RS13995 (2806150)	2806150..2806587	-	438	WP_002389480.1	peptide-methionine (R)-S-oxide reductase MsrB	-
LMJ46_RS14000 (2806720)	2806720..2807274	-	555	WP_002389433.1	nucleoside triphosphate pyrophosphatase	-
LMJ46_RS14005 (2807299)	2807299..2809431	-	2133	WP_002389406.1	DNA mismatch repair endonuclease MutL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5311.50 Da
• Isoelectric Point: 10.8331

>T223232 WP_002367458.1 NZ_CP086411:c2804772-2804629 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 144 bp

>T223232 NZ_CP118601:1131733-1132068 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Nucleotide

• Length: 187 bp

>AT223232 NZ_CP086411:2804510-2804696 [Enterococcus faecalis]
TGTGCTAGAATGTAGATGAAAAGAGAGATATGCGTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGACGGTGACCGATT
GTATTATTTAAAAATAACCGTACTGGTCAAAGTAGATGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGTG
CAATCAAAGCAATGGTAAACATACCAA

Structures

Antitoxin