Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3116781..3117441 Replicon chromosome
Accession NZ_CP086408
Organism Enterobacter cloacae strain POL9

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LMJ45_RS15000 Protein ID WP_128310913.1
Coordinates 3117067..3117441 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LMJ45_RS14995 Protein ID WP_014832568.1
Coordinates 3116781..3117083 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMJ45_RS14975 (LMJ45_14975) 3112623..3114812 + 2190 WP_013097826.1 TonB-dependent siderophore receptor -
LMJ45_RS14985 (LMJ45_14985) 3115222..3115611 - 390 WP_013097827.1 RidA family protein -
LMJ45_RS14990 (LMJ45_14990) 3115753..3116685 + 933 WP_128310914.1 LysR family transcriptional regulator -
LMJ45_RS14995 (LMJ45_14995) 3116781..3117083 - 303 WP_014832568.1 XRE family transcriptional regulator Antitoxin
LMJ45_RS15000 (LMJ45_15000) 3117067..3117441 - 375 WP_128310913.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LMJ45_RS15005 (LMJ45_15005) 3117800..3118750 - 951 WP_013097829.1 HTH-type transcriptional regulator Cbl -
LMJ45_RS15010 (LMJ45_15010) 3118847..3119764 - 918 WP_010432103.1 nitrogen assimilation transcriptional regulator NAC -
LMJ45_RS15020 (LMJ45_15020) 3120247..3121182 - 936 WP_128310912.1 L,D-transpeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-79)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14329.38 Da        Isoelectric Point: 9.7082

>T223209 WP_128310913.1 NZ_CP086408:c3117441-3117067 [Enterobacter cloacae]
VWTIITTDRFDCWFRSLDDTDRASVLAALLVLREKGPALSRPYADTLKGSRHSNMKELRIQSKGDPLRAFFAFDPNRTGI
VLCAGNKVGNERRFYDEMLLVADREFTHWLNTLKERTLRDGQKP

Download         Length: 375 bp

>T223209 NZ_CP118582:c2624157-2623855 [Vibrio harveyi]
ATGGCTGAAATAATCTGGACTGAACCAGCGTTATCTGACCTCAATGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTCGAACGTCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CTGAGCTAGAACACTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTATTTGTTATGCGTGCAGAGAGAGATTTGCGAAAGTTCCTGTTGAGTAAACAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10972.69 Da        Isoelectric Point: 5.1473

>AT223209 WP_014832568.1 NZ_CP086408:c3117083-3116781 [Enterobacter cloacae]
MGRNLEQLIADEKSDVVASAQAMAADILLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLTLDVELPDGSHYEFVL

Download         Length: 303 bp

>AT223209 NZ_CP118582:c2624402-2624145 [Vibrio harveyi]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAGCCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCTTATCTCGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTATCTGACGGTAAAATGGTAAGCCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References