Detailed information of TA system TA223139

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2102835..2103424
• Replicon: chromosome
• Accession: NZ_CP086372
• Organism: Xanthomonas oryzae pv. oryzae strain GXO2001

Toxin (Protein)

• Gene name: graT
• Uniprot ID: G7TIR7
• Locus tag: LNP58_RS09990
• Protein ID: WP_012443754.1
• Coordinates: 2102835..2103116 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LNP58_RS09995
• Protein ID: WP_011260746.1
• Coordinates: 2103134..2103424 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LNP58_RS09985 (LNP58_09975)	2100488..2102740	+	2253	WP_069960050.1	exodeoxyribonuclease V subunit alpha	-
LNP58_RS09990 (LNP58_09980)	2102835..2103116	+	282	WP_012443754.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LNP58_RS09995 (LNP58_09985)	2103134..2103424	+	291	WP_011260746.1	HigA family addiction module antitoxin	Antitoxin
LNP58_RS10000 (LNP58_09990)	2104353..2105747	+	1395	WP_027703652.1	type III secretion system effector XopQ	-
LNP58_RS10005 (LNP58_09995)	2105850..2106037	-	188	Protein_1921	hypothetical protein	-
LNP58_RS10010 (LNP58_10000)	2106197..2106529	-	333	WP_011260743.1	hypothetical protein	-
LNP58_RS10015 (LNP58_10005)	2106784..2107110	+	327	WP_228329596.1	hypothetical protein	-
LNP58_RS10020 (LNP58_10010)	2107238..2107660	+	423	WP_042465811.1	PAAR domain-containing protein	-
LNP58_RS10025 (LNP58_10015)	2107663..2108271	+	609	WP_011409746.1	DUF4123 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (2-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-68)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11066.83 Da
• Isoelectric Point: 10.5318

>T223139 WP_012443754.1 NZ_CP086372:2102835-2103116 [Xanthomonas oryzae pv. oryzae]
VIRSFIDKDAEKIWLGERSRRLPADIQLVARRKLRMLNAAAHLDDLRIPPANRLEALKGQRRGQYSIRINDQWRICFRWM
EGDVVQVEIVDYH

Nucleotide

• Length: 282 bp

>T223139 NZ_CP118537:c4158045-4157557 [Salmonella enterica subsp. enterica serovar Typhi]
ATGATCTCCGCCCCTGAACCGCTTCATGCCGGGCATATTCTTACCCCCTTCTGCTGCGGTGTGGATTCAATGGATAACTG
GCTAAAACAGCGGGCGATGAAAAATCAGGTAACTGGCGCATCCCGTACCTTTGTGTGTTGCGGCAGCGATTCTGACGTAC
TGGCGTATTATTCGCTGGCGTCCAGCGCGGTAACGACAAACACCGCCCCCGGTCGCTTTCGTCGCAATATGCCCGATCCG
ATCCCGGTTGTGGTGCTGGGCCGTCTGGCGGTGGATCGGTCGCTACATGGGCAGGGCGTAGGTCGGGCGCTGGTGAGGGA
TGCCGGGCTGCGGGTGATTCAGGTGGCGGAAACTATCGGTATTCGCGGGATGCTGGTCCATGCCCTGTCGGATGAAGCGC
GGGAGTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTT
CATGCCTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10420.07 Da
• Isoelectric Point: 7.2040

>AT223139 WP_011260746.1 NZ_CP086372:2103134-2103424 [Xanthomonas oryzae pv. oryzae]
MTVLPNIHPGDILLEEFLEPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTSERFWLGLQADYELEQA
HRALGDLPARIKRLAA

Nucleotide

• Length: 291 bp

>AT223139 NZ_CP118537:c4158335-4158042 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCCAGTCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGCATCAAGCCCGCCGAGCGCGATCTTATCGA
TCGGGCTGCAAAAGCCAGAGGGAAAAACTGCACAGACTTTGTGCTAGAAGCTGCCCGCGCCGCCGCCGAGGAAGCGCTGA
TCGAGCAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGCATTTCTGATCCGTCTGGATCAGGCTCCTGCGCCAAAC
GATGCGTTGCGTAAAACCATGCAGACTCCTGCACCGTGGGAGCAGGAAAAATGA

Structures

Toxin

• AlphaFold DB: A0A0K0GFW5