Detailed information of TA system TA022311

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE(toxin)
• Location: 725138..725765
• Replicon: chromosome
• Accession: NC_009663
• Organism: Sulfurovum sp. NBC37-1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A6Q852
• Locus tag: SUN_RS03650
• Protein ID: WP_011980394.1
• Coordinates: 725138..725458 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: SUN_RS03655
• Protein ID: WP_011980395.1
• Coordinates: 725451..725765 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SUN_RS03605	720254..720706	+	453	WP_011980387.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
SUN_RS03610	720760..721302	+	543	WP_011980388.1	DUF72 domain-containing protein	-
SUN_RS13690	721315..721425	+	111	WP_198407653.1	hypothetical protein	-
SUN_RS03615	721433..721681	+	249	Protein_710	ORF6N domain-containing protein	-
SUN_RS03620	721839..722141	+	303	WP_011980389.1	hypothetical protein	-
SUN_RS03625	722264..722521	+	258	WP_011980390.1	hypothetical protein	-
SUN_RS03630	722511..722894	+	384	WP_011980391.1	PIN domain-containing protein	-
SUN_RS03635	722918..723805	+	888	WP_011980392.1	SEL1-like repeat protein	-
SUN_RS03640	723952..724167	-	216	WP_011980393.1	hypothetical protein	-
SUN_RS13565	724650..724814	+	165	WP_158298176.1	hypothetical protein	-
SUN_RS03650	725138..725458	+	321	WP_011980394.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SUN_RS03655	725451..725765	+	315	WP_011980395.1	helix-turn-helix domain-containing protein	Antitoxin
SUN_RS13320	725878..726039	+	162	WP_083760394.1	type II toxin-antitoxin system RelE/ParE family toxin	-
SUN_RS03665	726032..726361	+	330	WP_011980396.1	helix-turn-helix domain-containing protein	-
SUN_RS03670	726426..726857	+	432	WP_011980397.1	ORF6N domain-containing protein	-
SUN_RS03675	727099..727434	+	336	WP_011980398.1	hypothetical protein	-
SUN_RS03680	727434..727796	+	363	WP_011980399.1	helix-turn-helix domain-containing protein	-
SUN_RS03690	728274..728603	+	330	WP_011980400.1	winged helix-turn-helix domain-containing protein	-
SUN_RS03695	728600..729127	+	528	WP_011980401.1	hypothetical protein	-
SUN_RS03700	729244..729423	+	180	WP_011980402.1	DUF2892 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (43-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (42-94)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12375.26 Da
• Isoelectric Point: 9.6236

>T22311 WP_011980394.1 NC_009663:725138-725458 [Sulfurovum sp. NBC37-1]
MIFIESKLFEKLREKYLEDENYRQLQNFLLEQPLAGDVIQGTGGLRKVRWSANDKGKRGGIRTIYLYITDKSHIHFLTLY
AKNEVSDLTTQEKKILKSIVEELKNG

Nucleotide

• Length: 321 bp

>T22311 NC_009663:725138-725458 [Sulfurovum sp. NBC37-1]
ATGATATTTATAGAATCAAAGTTATTTGAGAAGTTACGTGAAAAGTATCTGGAAGATGAGAACTATCGTCAATTGCAGAA
CTTTTTACTAGAACAGCCTTTGGCTGGTGATGTTATACAAGGTACCGGTGGACTACGAAAAGTCCGTTGGTCTGCCAATG
ATAAAGGTAAGAGAGGTGGTATTCGCACTATTTATCTTTACATCACAGACAAAAGCCATATTCACTTTTTGACTTTGTAT
GCCAAAAATGAAGTAAGTGATCTGACTACACAGGAAAAGAAGATACTCAAAAGTATCGTAGAGGAGTTAAAAAATGGCTA
A

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12013.85 Da
• Isoelectric Point: 8.5039

>AT22311 WP_011980395.1 NC_009663:725451-725765 [Sulfurovum sp. NBC37-1]
MAKRDLFEELKTGLEDAKAFEQDKLTLKTISITPKERKVLSADEIRSIREKYNMSRALFANFLHISPRTLEKWELGTSRP
NEQASTLLALTDKYPDMIERLGTI

Nucleotide

• Length: 315 bp

>AT22311 NC_009663:725451-725765 [Sulfurovum sp. NBC37-1]
ATGGCTAAAAGAGATTTATTTGAAGAGTTAAAAACTGGGCTTGAAGATGCCAAAGCCTTTGAACAAGACAAACTGACACT
TAAAACCATATCTATTACACCTAAAGAACGCAAAGTATTATCTGCAGATGAGATACGCTCCATTAGAGAAAAGTACAACA
TGAGCCGTGCACTTTTCGCAAACTTTCTGCACATCTCACCACGCACGCTGGAAAAATGGGAACTAGGCACAAGCCGACCA
AATGAACAGGCTTCCACCCTACTTGCTTTGACAGACAAGTATCCCGATATGATAGAAAGGTTAGGGACGATTTAA

Structures

Toxin

• AlphaFold DB: A6Q852