Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-HTH |
| Location | 2097143..2097615 | Replicon | chromosome |
| Accession | NZ_CP086368 | ||
| Organism | Bordetella pertussis CS | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | LMF30_RS10185 | Protein ID | WP_019247906.1 |
| Coordinates | 2097445..2097615 (-) | Length | 57 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LMF30_RS10180 | Protein ID | WP_010930491.1 |
| Coordinates | 2097143..2097442 (-) | Length | 100 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LMF30_RS10170 (LMF30_10170) | 2093251..2093925 | - | 675 | WP_010930489.1 | response regulator transcription factor | - |
| LMF30_RS10175 (LMF30_10175) | 2094055..2097129 | + | 3075 | WP_023995112.1 | autotransporter SphB2 | - |
| LMF30_RS10180 (LMF30_10180) | 2097143..2097442 | - | 300 | WP_010930491.1 | NadS family protein | Antitoxin |
| LMF30_RS10185 (LMF30_10185) | 2097445..2097615 | - | 171 | WP_019247906.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LMF30_RS10190 (LMF30_10190) | 2097757..2098380 | - | 624 | WP_010930492.1 | glutathione S-transferase N-terminal domain-containing protein | - |
| LMF30_RS10195 (LMF30_10195) | 2098624..2099493 | + | 870 | WP_010930493.1 | TauD/TfdA family dioxygenase | - |
| LMF30_RS10200 (LMF30_10200) | 2099471..2100415 | - | 945 | WP_010930494.1 | LysR family transcriptional regulator | - |
| LMF30_RS10205 (LMF30_10205) | 2100501..2101523 | - | 1023 | WP_023852774.1 | tripartite tricarboxylate transporter substrate binding protein | - |
| LMF30_RS10210 (LMF30_10210) | 2101540..2102313 | - | 774 | WP_010930496.1 | SDR family NAD(P)-dependent oxidoreductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 57 a.a. Molecular weight: 6461.57 Da Isoelectric Point: 9.7782
>T223107 WP_019247906.1 NZ_CP086368:c2097615-2097445 [Bordetella pertussis CS]
MHYGRQGTGKRGGIRVIYYWISQDCQIYMLAAYAKSKKINLTPDEIAALRELVKEL
MHYGRQGTGKRGGIRVIYYWISQDCQIYMLAAYAKSKKINLTPDEIAALRELVKEL
Download Length: 171 bp
>T223107 NZ_CP118496:2634980-2635930 [Pseudoalteromonas rhizosphaerae]
ATGCAAGTTGATAGCGATTTATTTTTAGATGTAGCAGATGCTCTTGGTATGGGTAACCCTGCCATTGTTGAAAAAGATTA
TTACGTAGTTGCATTGCTAAAGCTACTTTCAGAGTTATTTTTTGATACGCATTTTTTAGTTTTTTCAGGTGGTACGGCAT
TAACAAAGTCAGGCATTAAAACTCATCGAATGTCTGAAGATGTTGATATAAAAATCATTCCTAAAGATTTAGCTGCTAAC
ACCTCTAAAACTAAAAGAAGAAAGGCAAGAAAAGCGCTCCATTTACAGTTAATTGATGCAATTAATTCATATGATTATTT
TTCTGTAGAAAATGCTCCAACCGTTTTTGATGAATATCGATATCAACAAATTGATATTCGTTATCCTCAAGCCCATTCAA
AAGCTCCATGCTTACGACCGTTTATTAAATTAGAGCTTATTGAAACGTTACTTTTTGATAATGTACAAAGCCGCAATATA
TCTTCTTTAGTGAACGAGATAACTCAACAGGCACCAGAAGTGCCGCTGATGGATTTTTCTAGCATTAAGAGTACACAAGC
TGAAAAGTTAGTGTCTATGCTTAGGCGCACAGCGAGCTTTGCACGTGATAATAGAAGAGACGATGATCCTGCGCTAATTC
GCCATATTTATGATACGTATTATATTCAACAAGCTGGATTGGCGAATGTTCAAGATGTAGTACCTTTAGTGCAAAAAGTC
ATCGCGGAAGATATTACTCGTTATGGTAATCAGCATGCAGAATTTATGGAAAATCCGATTACTGAACTTAGGTTTGCTTT
AGGTGTATTACAAGCGAATTCAATTTATGAAGCGCGTTTTAATAAATATGTCGTGCCAATGGTTTATGGTAATCATAGCC
TTAATTGGGAGCATGCATTTGATGTATTTAAGTTATATTGCGACCAAGTACTAAATAATATAAAGCTTTAA
ATGCAAGTTGATAGCGATTTATTTTTAGATGTAGCAGATGCTCTTGGTATGGGTAACCCTGCCATTGTTGAAAAAGATTA
TTACGTAGTTGCATTGCTAAAGCTACTTTCAGAGTTATTTTTTGATACGCATTTTTTAGTTTTTTCAGGTGGTACGGCAT
TAACAAAGTCAGGCATTAAAACTCATCGAATGTCTGAAGATGTTGATATAAAAATCATTCCTAAAGATTTAGCTGCTAAC
ACCTCTAAAACTAAAAGAAGAAAGGCAAGAAAAGCGCTCCATTTACAGTTAATTGATGCAATTAATTCATATGATTATTT
TTCTGTAGAAAATGCTCCAACCGTTTTTGATGAATATCGATATCAACAAATTGATATTCGTTATCCTCAAGCCCATTCAA
AAGCTCCATGCTTACGACCGTTTATTAAATTAGAGCTTATTGAAACGTTACTTTTTGATAATGTACAAAGCCGCAATATA
TCTTCTTTAGTGAACGAGATAACTCAACAGGCACCAGAAGTGCCGCTGATGGATTTTTCTAGCATTAAGAGTACACAAGC
TGAAAAGTTAGTGTCTATGCTTAGGCGCACAGCGAGCTTTGCACGTGATAATAGAAGAGACGATGATCCTGCGCTAATTC
GCCATATTTATGATACGTATTATATTCAACAAGCTGGATTGGCGAATGTTCAAGATGTAGTACCTTTAGTGCAAAAAGTC
ATCGCGGAAGATATTACTCGTTATGGTAATCAGCATGCAGAATTTATGGAAAATCCGATTACTGAACTTAGGTTTGCTTT
AGGTGTATTACAAGCGAATTCAATTTATGAAGCGCGTTTTAATAAATATGTCGTGCCAATGGTTTATGGTAATCATAGCC
TTAATTGGGAGCATGCATTTGATGTATTTAAGTTATATTGCGACCAAGTACTAAATAATATAAAGCTTTAA
Antitoxin
Download Length: 100 a.a. Molecular weight: 11036.80 Da Isoelectric Point: 11.0499
>AT223107 WP_010930491.1 NZ_CP086368:c2097442-2097143 [Bordetella pertussis CS]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTDPAMA
LLKIVASAPDIAVRALRTA
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTDPAMA
LLKIVASAPDIAVRALRTA
Download Length: 300 bp
>AT223107 NZ_CP118496:2634592-2634990 [Pseudoalteromonas rhizosphaerae]
ATGACAATAGCAAGTAAAGTAACGACAAGAATAAATCGCTCTAGGCGTTATGTTTTTGAGCGCGCTGATTTTGCTGATAT
TGCTGGTTACGACCAAGTGGGACGGGTCTTAAAAAAACTGGTTGATAGTGGCCAGTTGTTACGTATTGGGTATGGGCTTT
ATACCAAAGCGCGAGAAAATCGCATTACTGGCAAGTTAATGCCAGCATCACCTGCGGGAGCTGATGGAGTCATTTTAGAG
GCTATTGAAAAACTGGGCGTTGAGTATCAATTTGATGAATTTTCACAACGCAGTCTTAATGGTGAAAGTTTACAAGTTCC
CGCTTCATTTAAAATAATGACCAATAGTCGATTTAAGCGCAAGATTGTTGTAAATAATAGCGCTATCAATGCAAGTTGA
ATGACAATAGCAAGTAAAGTAACGACAAGAATAAATCGCTCTAGGCGTTATGTTTTTGAGCGCGCTGATTTTGCTGATAT
TGCTGGTTACGACCAAGTGGGACGGGTCTTAAAAAAACTGGTTGATAGTGGCCAGTTGTTACGTATTGGGTATGGGCTTT
ATACCAAAGCGCGAGAAAATCGCATTACTGGCAAGTTAATGCCAGCATCACCTGCGGGAGCTGATGGAGTCATTTTAGAG
GCTATTGAAAAACTGGGCGTTGAGTATCAATTTGATGAATTTTCACAACGCAGTCTTAATGGTGAAAGTTTACAAGTTCC
CGCTTCATTTAAAATAATGACCAATAGTCGATTTAAGCGCAAGATTGTTGTAAATAATAGCGCTATCAATGCAAGTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|