Detailed information of TA system TA223106

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1944070..1944725
• Replicon: chromosome
• Accession: NZ_CP086368
• Organism: Bordetella pertussis CS

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: LMF30_RS09490
• Protein ID: WP_047122780.1
• Coordinates: 1944070..1944321 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: LMF30_RS09495
• Protein ID: WP_003809516.1
• Coordinates: 1944324..1944725 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LMF30_RS09465 (LMF30_09465)	1939231..1940361	-	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-
LMF30_RS09470 (LMF30_09470)	1940596..1941177	+	582	WP_019247931.1	MOSC domain-containing protein	-
LMF30_RS09475 (LMF30_09475)	1941314..1942378	+	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
LMF30_RS09480 (LMF30_09480)	1942463..1942909	-	447	WP_003819827.1	GFA family protein	-
LMF30_RS09485 (LMF30_09485)	1943134..1944015	+	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
LMF30_RS09490 (LMF30_09490)	1944070..1944321	+	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
LMF30_RS09495 (LMF30_09495)	1944324..1944725	+	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
LMF30_RS09500 (LMF30_09500)	1944745..1944981	+	237	WP_010930404.1	DUF5993 family protein	-
LMF30_RS09505 (LMF30_09505)	1944989..1945468	+	480	WP_010930405.1	disulfide bond formation protein B	-
LMF30_RS09510 (LMF30_09510)	1945618..1946133	+	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
LMF30_RS09515 (LMF30_09515)	1946136..1947326	+	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
LMF30_RS09520 (LMF30_09520)	1947346..1948383	+	1038	WP_023853543.1	L-threonylcarbamoyladenylate synthase	-
LMF30_RS09525 (LMF30_09525)	1948520..1949542	+	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T223106 WP_047122780.1 NZ_CP086368:1944070-1944321 [Bordetella pertussis CS]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T223106 NZ_CP118496:c2614483-2613593 [Pseudoalteromonas rhizosphaerae]
ATGCTAACAGAATATATACGCCAAATTATAGCTGCAAATCCAGAGTACGCTGGCGTCACGCCTGTGATTGAAAAAGAAAT
TCTTCATCACGACATTATGGCTGCAATGGTAAAACAAGGTGTTATGCCTTCGCTTACTTTTATTGGTGGCACCTCACTTC
GTTTGTGCCATAACAGTTCTAGATTATCTGAGGATTTAGATTTTAATGGTGGGCATGACTTCAAGCCAAGTAGTTTCAGT
GGCTTAGAAGTTGAAATCCAAAAATACATACAAAATAAATATGAGGTGCAGGTATGGGTAAATAAACCAGCTGAAGATAA
TCAAGCTAATACTTCATCTTGGAAAATAAGTATCGAAAAAGAAAGTAATCGTCCTGATCTTCCCCGCCAAAAAATGCATA
TAGATATTTGCGCTATCCCTTCATTTGATATCGAAAAAAGGCCATTAATAAATCACTATAATATTGTCGCGCCAACAGAA
GGTTTACTGATCCCTGTACAATCATTAACGGAAACGCTTGCAGACAAGTTTATTGCATTAGCCTACCCTGCTAGGCGCAT
TAAACCGCGCGATGTATGGGATATAGTTTGGATAAAACAAAGAGGTGTTGCGGTATCTAAGCAACTGATCAATAAAAAGC
TTGTGGCCAGGGGTAAAACCAACGAAGACTTTATTGAGGCACTGACTATTCAATTAGACAAGCTACAGCATGACGATGAA
GTTCGTAAAGACTTCAATATTGAAATGAGCCGTTTCATTCCAAATCAAATCAAAGAAAGAACAATCGATAACCCTGATTA
TTGGCCATATGTACAATCAGAAATTAGTACTATGTCACTCTCAATCCTTAATAATGGTATTAAAAATAATAAGTTTGATA
TGGGGAGCTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT223106 WP_003809516.1 NZ_CP086368:1944324-1944725 [Bordetella pertussis CS]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT223106 NZ_CP118496:c2615008-2614484 [Pseudoalteromonas rhizosphaerae]
ATGAATAAAGCAGAAAGATTATTAGCAATACTAGCTAGCTCTGTTAAAGCAGGTGGCGGTATTCATACCAGTGCAGAATT
GGCTTTTATGATGGCTGAAAAACCCACTCCTGCATTCACTAAGTTTCTGACTGACAATGTTAATAAAGGACTATTAAGAA
GAGTCTGCAATGGTATTTTTGAAAGCACGCTCACGCCACCTGACCCCACCACCGCTATTTATAAAATAGTTAAAAAACTA
CGTGGCGACGTTTTAAATTACATTAGCCTAGAAAGCCAGCTCAGTTACACGGGCGATATTTCGCAAATATTAATGGATAG
GTTAACGGTAATAACGAAAGGTCGTAGTGGCACATTTTCAACTCCGTATGGGGTTATTGAGCTGACCCATACAAAAAAAC
CAATTGATAAATTTGCGAAAAACCTATATTTCGATAAAAGCATCAAGATGTACCGAGCAAATACGCTGCAAGCGATTGCG
GATCTAAAAGCCTGCAATCGCAACGTACACATGCTGGAGAACTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6