Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3870487..3871180 Replicon chromosome
Accession NZ_CP086338
Organism Escherichia coli strain EJN001

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag C5N09_RS18730 Protein ID WP_000415584.1
Coordinates 3870884..3871180 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag C5N09_RS18725 Protein ID WP_000650107.1
Coordinates 3870487..3870882 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5N09_RS18715 (3866351) 3866351..3868609 - 2259 WP_032329482.1 DNA topoisomerase IV subunit A -
C5N09_RS18720 (3868747) 3868747..3870354 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
C5N09_RS18725 (3870487) 3870487..3870882 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
C5N09_RS18730 (3870884) 3870884..3871180 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
C5N09_RS18735 (3871385) 3871385..3871867 - 483 WP_000183505.1 GyrI-like domain-containing protein -
C5N09_RS18740 (3871920) 3871920..3872312 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
C5N09_RS18745 (3872464) 3872464..3873123 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
C5N09_RS18750 (3873120) 3873120..3874469 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
C5N09_RS18755 (3874515) 3874515..3874847 - 333 WP_000917685.1 DUF2645 family protein -
C5N09_RS18760 (3875166) 3875166..3875747 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
C5N09_RS18765 (3875778) 3875778..3876092 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T223050 WP_000415584.1 NZ_CP086338:c3871180-3870884 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T223050 NZ_CP118332:4072941-4073309 [Klebsiella aerogenes]
ATGAATACTTTACCTGCAATAAACCAGCGGGCTGTTCAGACATGCTTATCACCCGTGGTTGTCTGGCAAATGCTGCTTGC
TCGACTACTTGAGCAGCACTATGGCCTGACCTTAAATGACACGCCGTTCAGCGATGAGGCTGTTATTAAAAGACATATCG
AAGCTGGTATCACGCTTGTCGATGCCGTTAATTTTCTGGTGGAGAAGTACGAATTGATCCGTATCGACCGCAGAGGATTT
AGCTCACAGGGACAAGTGCCATATTTGACCGTGACAGATATCCTTCATGCCAGGAGAGCATGTGGATTAACGAACAGTTG
TCCTTATCGGGAAGTAAGTAATATTGTTCTTGGCCGATCGCGGCAGTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT223050 WP_000650107.1 NZ_CP086338:c3870882-3870487 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT223050 NZ_CP118332:4072556-4072906 [Klebsiella aerogenes]
ATGTCGAGTAAGACACTCACAGTGAATGATGATACTGCTGAGCCCTGGTGGGGGCTGAATCGTAATGTCATTCCTTGTTT
TGGTGCGCGTCTGGTCCAGGAAGGTAACCGCCTATATTACCTGTCTGACCGCGCCAGCATAATAGGCCTATTCAATAAAG
CGGATTTGCTCCGTCTTGACCAGGCATTTCCTGTTCTGCTGAAGCAGGCGGAGCTCATGCTTACCAGCGGCGAACTGAAT
CCCCGACACCAGCATTGCGTCACCCTCTATGCAAAGGGGCTGACCTGCGAAGCTGATACGCTGGGTTCCTGTGGTCACGT
CTATATCTCCATTTATCCTACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References