Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1949164..1949666 | Replicon | chromosome |
| Accession | NZ_CP086259 | ||
| Organism | Escherichia coli strain SCPM-O-B-9427 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | LMH79_RS09285 | Protein ID | WP_000767829.1 |
| Coordinates | 1949412..1949666 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | LMH79_RS09280 | Protein ID | WP_001259255.1 |
| Coordinates | 1949164..1949415 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LMH79_RS09255 (1944342) | 1944342..1945409 | - | 1068 | WP_097307568.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| LMH79_RS09260 (1945409) | 1945409..1946479 | - | 1071 | WP_097307567.1 | histidinol-phosphate transaminase | - |
| LMH79_RS09265 (1946476) | 1946476..1947780 | - | 1305 | WP_001542955.1 | histidinol dehydrogenase | - |
| LMH79_RS09270 (1947786) | 1947786..1948685 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| LMH79_RS09275 (1948831) | 1948831..1948881 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| LMH79_RS09280 (1949164) | 1949164..1949415 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| LMH79_RS09285 (1949412) | 1949412..1949666 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| LMH79_RS09290 (1949749) | 1949749..1950573 | + | 825 | WP_170903132.1 | SDR family oxidoreductase | - |
| LMH79_RS09295 (1950619) | 1950619..1951548 | + | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| LMH79_RS09300 (1951763) | 1951763..1951825 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| LMH79_RS09305 (1951815) | 1951815..1953173 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| LMH79_RS09310 (1953352) | 1953352..1954410 | + | 1059 | WP_000492346.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| LMH79_RS09315 (1954424) | 1954424..1954651 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T222857 WP_000767829.1 NZ_CP086259:1949412-1949666 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T222857 NZ_CP118147:c570878-570450 [Pseudomonas chlororaphis]
ATGATCGTGCTCGACACTAATGTGCTGTCGGAACTGATGCGTCCCCAACCGGACGCATCGGTATTGCTGTGGATCGAAGC
GCAACCTGTCGAAGACCTCTACATCAGCGCCATGACCATGGCCGAGATTCTTCACGGCATCGCGCGCCTGCCCCACGGCA
AGCGCAAACAGATGCTCCATGCGTCGGCGCTCGCGATGTTCGAGGAAGATTTCATCGACCGCATCGTGCCCTTCGGGACC
CAGGCGGCTCTTTACTACGCCCATCTGATTTCGCACCGGGAAAGCCTGGGGCGTCCGATCAGCCTGGTGGATGCGCAAAT
CGCGGCCATATGCCGCGTCCACGACGCGGCGATCGCCACCCGTAACGCCAAGGACTTCAGCGATACAGGGTTGATCGTTA
TCAACCCCTGGCTGCCACTCGAGGTTTGA
ATGATCGTGCTCGACACTAATGTGCTGTCGGAACTGATGCGTCCCCAACCGGACGCATCGGTATTGCTGTGGATCGAAGC
GCAACCTGTCGAAGACCTCTACATCAGCGCCATGACCATGGCCGAGATTCTTCACGGCATCGCGCGCCTGCCCCACGGCA
AGCGCAAACAGATGCTCCATGCGTCGGCGCTCGCGATGTTCGAGGAAGATTTCATCGACCGCATCGTGCCCTTCGGGACC
CAGGCGGCTCTTTACTACGCCCATCTGATTTCGCACCGGGAAAGCCTGGGGCGTCCGATCAGCCTGGTGGATGCGCAAAT
CGCGGCCATATGCCGCGTCCACGACGCGGCGATCGCCACCCGTAACGCCAAGGACTTCAGCGATACAGGGTTGATCGTTA
TCAACCCCTGGCTGCCACTCGAGGTTTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT222857 WP_001259255.1 NZ_CP086259:1949164-1949415 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT222857 NZ_CP118147:c571120-570875 [Pseudomonas chlororaphis]
ATGGCCAGCCTGACAATCCGAAACCTGGACGACCACATCAAAGAGCGCCTGCGCATCGAGGCCGCCCACAACGGCCACTC
CATGGAAGAAGAAGCCCGCTTGATTTTGCGCCGCGCCCTGAACAGAACAACCGACAGCCAAGGCCTGGCCAGTCGTATCC
GGGCACGCTTTGCCGAGGCCGGCGGAGTGAAGCTTGAGCTGCCCGAACGTACCGAGCCGGCACGCGTGGTGGATCTGGGC
GAATGA
ATGGCCAGCCTGACAATCCGAAACCTGGACGACCACATCAAAGAGCGCCTGCGCATCGAGGCCGCCCACAACGGCCACTC
CATGGAAGAAGAAGCCCGCTTGATTTTGCGCCGCGCCCTGAACAGAACAACCGACAGCCAAGGCCTGGCCAGTCGTATCC
GGGCACGCTTTGCCGAGGCCGGCGGAGTGAAGCTTGAGCTGCCCGAACGTACCGAGCCGGCACGCGTGGTGGATCTGGGC
GAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|