Detailed information of TA system TA222839

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/HipA(toxin)
• Location: 4319746..4321097
• Replicon: chromosome
• Accession: NZ_CP086253
• Organism: Pectobacterium aquaticum strain A212-S19-A16

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: -
• Locus tag: DMB82_RS20000
• Protein ID: WP_116163877.1
• Coordinates: 4320057..4321097 (+)
• Length: 347 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: -
• Locus tag: DMB82_RS19995
• Protein ID: WP_102118768.1
• Coordinates: 4319746..4320060 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DMB82_RS19975 (DMB82_0020035)	4315379..4317082	+	1704	WP_116163883.1	ABC transporter ATP-binding protein	-
DMB82_RS19980 (DMB82_0020040)	4317084..4318118	+	1035	WP_116163881.1	putative FMN-dependent luciferase-like monooxygenase	-
DMB82_RS19985 (DMB82_0020045)	4318115..4319248	+	1134	WP_116163879.1	alkylhydroperoxidase domain protein	-
DMB82_RS19990 (DMB82_0020050)	4319435..4319761	+	327	WP_039546304.1	helix-turn-helix domain-containing protein	-
DMB82_RS19995 (DMB82_0020055)	4319746..4320060	+	315	WP_102118768.1	HipA N-terminal domain-containing protein	Antitoxin
DMB82_RS20000 (DMB82_0020060)	4320057..4321097	+	1041	WP_116163877.1	HipA domain-containing protein	Toxin
DMB82_RS20005 (DMB82_0020065)	4321156..4321670	-	515	Protein_3907	LysE family translocator	-
DMB82_RS20010 (DMB82_0020070)	4321936..4322187	+	252	WP_102118771.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
DMB82_RS20015 (DMB82_0020075)	4322184..4322471	+	288	WP_039546296.1	type II toxin-antitoxin system RelE/ParE family toxin	-
DMB82_RS20020 (DMB82_0020080)	4322573..4323925	-	1353	WP_102118773.1	glutathione-disulfide reductase	-
DMB82_RS20025 (DMB82_0020085)	4324052..4324894	-	843	WP_102118774.1	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	-
DMB82_RS20030 (DMB82_0020090)	4325055..4325204	-	150	Protein_3912	Hsp70 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (57-307)

Antitoxin

• HipA, N-terminal subdomain 1 (5-98)

Sequences

Toxin

Protein

• Length: 347 a.a.
• Molecular weight: 39501.54 Da
• Isoelectric Point: 6.6159

>T222839 WP_116163877.1 NZ_CP086253:4320057-4321097 [Pectobacterium aquaticum]
MTRCRILLTPLTHEEESATGYSRKGLKHLTGSMHASPALRFTRQQFMHDLPQTQKGMSISGYQPKIQMVLEERAFTVVDH
QGLYILKPSPIEFPHLAENEHATMTLMARLGFAVPPHGLLCFKPEQADDEPEFAFVIKRFDRDEKTGHPIHQEQLDGAMG
IGEKFGKIRADGRQYVSYERLALFLSKHVNDNIVFKIDLFRRIAYAYMLGNNDMHLRNFGLIHSRSGSLMLAPIYDFVSV
APYPTYFSSCFMALPLLIQEEGDEALALGFETAYGEYLGMDFILFGQRIGLSEKLTKKLLADFIKEAECVESTYRDSFMP
AEAIDTTLRCYRHRLNLMSILDAERI

Nucleotide

• Length: 1041 bp

>T222839 NZ_CP118145:540052-540234 [Pseudomonas chlororaphis]
ATGCGCAGTCGGGAACTGATCAGGATGATCGAGGAGGACGGGTGGTATCTGATCGCGGTCAAAGGCAGTCATCACCAGTA
CAAGCATCTGCACAAGCCGGGGCGGGTCACTATCCCTCACCCGGATGCGGATCTGCCCAGGGGCACGATCCACAGCATCT
TGAAACAGGCGGGCCTGAAATGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11859.61 Da
• Isoelectric Point: 9.2441

>AT222839 WP_102118768.1 NZ_CP086253:4319746-4320060 [Pectobacterium aquaticum]
MRRQVKVYLYGVHIGQLSQDDKGYLFEYKKSYIGPPLSLSLPIQTGTFRSQTLPPYFASLAPEGWLRRQYSQLQHLDETD
LFGILIQNGKNLIGAVQLIAEDKS

Nucleotide

• Length: 315 bp

>AT222839 NZ_CP118145:540264-540665 [Pseudomonas chlororaphis]
ATGAAATTCCCGGTCGTGCTGCACAAGGATGCCGACTCCGGATATGGAGTGATCGTCCCCGATGTGCCGGGCTGTTTTTC
CGCCGGTCATACCGCGGCAGAAGCCTTCGAGAATGTGAAAGAGGCCCTGTCGCTGCATTACGAAGGCCTGGTCGCCGATG
GTGAACCGCTGCCCCAGGTGCATGAGGTCGACGTGCATATCGACAATCCCGATTACGCCGGTGGCGTGTGGGGCATGATC
GAGTTCGACATCACGCCTTACTTCGGCAAGGCGGTGCGCTTCAACGCCACCCTGCCGGAGCAATTGCTGGAACGCATCGA
CCAGACGGTGAAGCGCGACCAGCGCTACCGCTCGCGTTCGGGCTTTCTCGCCGCGGCGGCATTACGCGAGTTATCGGCGT
AG